NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399964" target="_blank" >RIV/00064165:_____/19:10399964 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/19:00507580 RIV/60460709:41210/19:80969 RIV/00216208:11110/19:10399964 RIV/00216208:11310/19:10399964

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LKs-7LHr5i" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LKs-7LHr5i</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nano9060888" target="_blank" >10.3390/nano9060888</a>

Jazyk výsledku

angličtina

Název v původním jazyce

NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans

Popis výsledku v původním jazyce

The present pilot study tested the efficiency of nanoTiO(2) sunscreen to prevent the oxidative stress/inflammation caused by ultraviolet (UV) radiation using biomarkers in subjects&apos; blood, urine, and exhaled breath condensate (EBC). In addition, the skin absorption of nanoTiO(2) was studied. Six identical subjects participated in three tests: (A) nanoTiO(2) sunscreen, (B) UV radiation, and (C) sunscreen + UV. The first samples were collected before the test and the second after sunscreen application and/or UV exposure. On day 4, the third samples were collected, and the sunscreen was washed off, and the fourth samples were collected on day 11. The following biomarkers were measured: malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, aldehydes C6-C12, 8-iso-Prostaglandin F2 alpha, o-tyrosine, 3-chlorotyrosine, 3-nitrotyrosine, 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, 5-hydroxymethyl uracil, and leukotrienes, using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Titania was measured using inductively coupled plasma mass spectrometry and TiO2 nanoparticles by transmission and scanning electron microscopy. Sunscreen alone did not elevate the markers, but UV increased the biomarkers in the plasma, urine, and EBC. The sunscreen prevented skin redness, however it did not inhibit the elevation of oxidative stress/inflammatory markers. Titania and nanoTiO(2) particles were found in the plasma and urine (but not in the EBC) in all sunscreen users, suggesting their skin absorption.

Název v anglickém jazyce

NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans

Popis výsledku anglicky

The present pilot study tested the efficiency of nanoTiO(2) sunscreen to prevent the oxidative stress/inflammation caused by ultraviolet (UV) radiation using biomarkers in subjects&apos; blood, urine, and exhaled breath condensate (EBC). In addition, the skin absorption of nanoTiO(2) was studied. Six identical subjects participated in three tests: (A) nanoTiO(2) sunscreen, (B) UV radiation, and (C) sunscreen + UV. The first samples were collected before the test and the second after sunscreen application and/or UV exposure. On day 4, the third samples were collected, and the sunscreen was washed off, and the fourth samples were collected on day 11. The following biomarkers were measured: malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, aldehydes C6-C12, 8-iso-Prostaglandin F2 alpha, o-tyrosine, 3-chlorotyrosine, 3-nitrotyrosine, 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, 5-hydroxymethyl uracil, and leukotrienes, using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Titania was measured using inductively coupled plasma mass spectrometry and TiO2 nanoparticles by transmission and scanning electron microscopy. Sunscreen alone did not elevate the markers, but UV increased the biomarkers in the plasma, urine, and EBC. The sunscreen prevented skin redness, however it did not inhibit the elevation of oxidative stress/inflammatory markers. Titania and nanoTiO(2) particles were found in the plasma and urine (but not in the EBC) in all sunscreen users, suggesting their skin absorption.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/GA18-02079S" target="_blank" >GA18-02079S: Vliv expozice nanočásticím na změny v DNA u lidské populace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomaterials

ISSN

2079-4991

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

23

Strana od-do

888

Kód UT WoS článku

000475352900082

EID výsledku v databázi Scopus

2-s2.0-85070237976