Blood Pressure Profile, Catecholamine Phenotype, and Target Organ Damage in Pheochromocytoma/Paraganglioma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10401100" target="_blank" >RIV/00064165:_____/19:10401100 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10401100 RIV/00216208:11120/19:43918122 RIV/00064173:_____/19:N0000140

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1gtnIPhqxB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1gtnIPhqxB</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2018-02644" target="_blank" >10.1210/jc.2018-02644</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Blood Pressure Profile, Catecholamine Phenotype, and Target Organ Damage in Pheochromocytoma/Paraganglioma

Popis výsledku v původním jazyce

CONTEXT: Impaired diurnal blood pressure (BP) variability is related to higher cardiovascular risk. OBJECTIVE: To assess diurnal variability of BP and its relation to target organ damage (TOD) and catecholamine phenotype in a consecutive sample of pheochromocytoma/paraganglioma (PPGL). DESIGN: We included 179 patients with PPGL (96 females). All patients underwent 24h ambulatory blood pressure monitoring (SpaceLabs 90207) to determine dipping status. Differences in plasma metanephrine or urine adrenaline were used to distinguish catecholamine biochemical phenotype. To evaluate TOD, renal functions, presence of left ventricle hypertrophy (LVH) and, in the subgroup (N=111) carotid-femoral PWV, were assessed. Structural equation modeling was used to find the relationship among nocturnal dipping, catecholamine phenotype and TOD parameters. RESULTS: According to the nocturnal dipping, patients were divided into the three groups -dippers (28 %), non-dippers (40 %) and reverse dippers (32 %). Reverse dippers were older (P&lt;0.05), with a higher proportion of noradrenergic phenotype (P&lt;0.05), a higher prevalence of diabetes mellitus (P&lt;0.05), sustained arterial hypertension (P&lt;0.01) and its duration (P&lt;0.05) as opposed to the other groups. All parameters of TOD were more pronounced only in reverse dippers, in comparison with non-dippers and dippers. The presence of noradrenergic biochemical phenotype (=absence of adrenaline production) was associated with reverse dipping and TOD (LVH and PWV). CONCLUSIONS: Only patients with reverse dipping had more significant TOD compared to other groups. The noradrenergic biochemical phenotype plays an important role not only in impaired diurnal BP variability, but also, independently from dipping status, in more pronounced TOD of heart and vessels.

Název v anglickém jazyce

Blood Pressure Profile, Catecholamine Phenotype, and Target Organ Damage in Pheochromocytoma/Paraganglioma

Popis výsledku anglicky

CONTEXT: Impaired diurnal blood pressure (BP) variability is related to higher cardiovascular risk. OBJECTIVE: To assess diurnal variability of BP and its relation to target organ damage (TOD) and catecholamine phenotype in a consecutive sample of pheochromocytoma/paraganglioma (PPGL). DESIGN: We included 179 patients with PPGL (96 females). All patients underwent 24h ambulatory blood pressure monitoring (SpaceLabs 90207) to determine dipping status. Differences in plasma metanephrine or urine adrenaline were used to distinguish catecholamine biochemical phenotype. To evaluate TOD, renal functions, presence of left ventricle hypertrophy (LVH) and, in the subgroup (N=111) carotid-femoral PWV, were assessed. Structural equation modeling was used to find the relationship among nocturnal dipping, catecholamine phenotype and TOD parameters. RESULTS: According to the nocturnal dipping, patients were divided into the three groups -dippers (28 %), non-dippers (40 %) and reverse dippers (32 %). Reverse dippers were older (P&lt;0.05), with a higher proportion of noradrenergic phenotype (P&lt;0.05), a higher prevalence of diabetes mellitus (P&lt;0.05), sustained arterial hypertension (P&lt;0.01) and its duration (P&lt;0.05) as opposed to the other groups. All parameters of TOD were more pronounced only in reverse dippers, in comparison with non-dippers and dippers. The presence of noradrenergic biochemical phenotype (=absence of adrenaline production) was associated with reverse dipping and TOD (LVH and PWV). CONCLUSIONS: Only patients with reverse dipping had more significant TOD compared to other groups. The noradrenergic biochemical phenotype plays an important role not only in impaired diurnal BP variability, but also, independently from dipping status, in more pronounced TOD of heart and vessels.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV16-30345A" target="_blank" >NV16-30345A: Feochromocytom jako model chronické aktivace stresové osy v patogenezi metabolických poruch</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Clinical Endocrinology &amp; Metabolism

ISSN

0021-972X

e-ISSN

—

Svazek periodika

104

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

5170-5180

Kód UT WoS článku

000497979600030

EID výsledku v databázi Scopus

2-s2.0-85071019278