Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk Factors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10404838" target="_blank" >RIV/00064165:_____/19:10404838 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10404838

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uPCsM82twI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uPCsM82twI</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk Factors

Popis výsledku v původním jazyce

Elevated plasma concentration of apolipoprotein B-48 (apoB-48) is an independent risk factor of cardiovascular disease. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipogenic enzyme and a key regulator of fuel metabolism. The aim of this study was to analyse associations between clinical, biochemical, and genetic factors and different apoB-48 levels in subjects at increased cardiometabolic risk. We examined 220 subjects exhibiting at least one metabolic syndrome (MetS) component. In conjunction with basic clinical, anthropometric and laboratory measurements, we analysed various polymorphisms of stearoyl-CoA desaturase-1 (SCD1). Subjects were divided into two groups according to the median apoB-48 level: (1) high apoB-48 (&gt;= 7.9 mg/l, N = 112) and (2) low apoB-48 (&lt; 7.9 mg/l, N = 108). Neither group differed significantly in anthropometric measures. High plasma apoB-48 levels were associated with increased systolic blood pressure (+3 %; P &lt; 0.05), MetS prevalence (59.8 vs. 32.4 %; P &lt; 0.001), small-dense LDL frequency (46.4 vs. 20.4 %; P &lt; 0.001), triglycerides (+97 %; P &lt; 0.001), non-HDL-cholesterol (+27 %; P &lt; 0.001), and lower concentrations of HDL-cholesterol (-11 %; P &lt; 0.01). This group was further characterized by a higher HOMA-IR index (+54 %; P &lt; 0.001) and increased concentrations of conjugated dienes (+11 %; P &lt; 0.001) and oxidatively modified LDL (+ 38 %; P &lt; 0.05). Lower frequencies of SCD1 minor genotypes (rs2167444, rs508384, P &lt; 0.05) were observed in subjects with elevated plasma concentrations of apoB-48. Elevated plasma concentrations of apoB-48 are associated with an adverse lipid profile, higher systolic blood pressure, insulin resistance, and oxidative stress. Lower proportions of minor SCD1 genotypes (rs2167444, rs508384) implicate the role of genetic factors in the pathogenesis of elevated levels of apoB-48.

Název v anglickém jazyce

Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk Factors

Popis výsledku anglicky

Elevated plasma concentration of apolipoprotein B-48 (apoB-48) is an independent risk factor of cardiovascular disease. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipogenic enzyme and a key regulator of fuel metabolism. The aim of this study was to analyse associations between clinical, biochemical, and genetic factors and different apoB-48 levels in subjects at increased cardiometabolic risk. We examined 220 subjects exhibiting at least one metabolic syndrome (MetS) component. In conjunction with basic clinical, anthropometric and laboratory measurements, we analysed various polymorphisms of stearoyl-CoA desaturase-1 (SCD1). Subjects were divided into two groups according to the median apoB-48 level: (1) high apoB-48 (&gt;= 7.9 mg/l, N = 112) and (2) low apoB-48 (&lt; 7.9 mg/l, N = 108). Neither group differed significantly in anthropometric measures. High plasma apoB-48 levels were associated with increased systolic blood pressure (+3 %; P &lt; 0.05), MetS prevalence (59.8 vs. 32.4 %; P &lt; 0.001), small-dense LDL frequency (46.4 vs. 20.4 %; P &lt; 0.001), triglycerides (+97 %; P &lt; 0.001), non-HDL-cholesterol (+27 %; P &lt; 0.001), and lower concentrations of HDL-cholesterol (-11 %; P &lt; 0.01). This group was further characterized by a higher HOMA-IR index (+54 %; P &lt; 0.001) and increased concentrations of conjugated dienes (+11 %; P &lt; 0.001) and oxidatively modified LDL (+ 38 %; P &lt; 0.05). Lower frequencies of SCD1 minor genotypes (rs2167444, rs508384, P &lt; 0.05) were observed in subjects with elevated plasma concentrations of apoB-48. Elevated plasma concentrations of apoB-48 are associated with an adverse lipid profile, higher systolic blood pressure, insulin resistance, and oxidative stress. Lower proportions of minor SCD1 genotypes (rs2167444, rs508384) implicate the role of genetic factors in the pathogenesis of elevated levels of apoB-48.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

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Svazek periodika

65

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

159-169

Kód UT WoS článku

000507623700001

EID výsledku v databázi Scopus

2-s2.0-85077480331