Cerebellum - aging of the neuronal machine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F21%3A10451418" target="_blank" >RIV/00064165:_____/21:10451418 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10451418

Výsledek na webu

<a href="https://doi.org/10.1016/B978-0-12-817990-1.00025-1" target="_blank" >https://doi.org/10.1016/B978-0-12-817990-1.00025-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-817990-1.00025-1" target="_blank" >10.1016/B978-0-12-817990-1.00025-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebellum - aging of the neuronal machine

Popis výsledku v původním jazyce

This chapter provides an overview of the structure of the cerebellum, the current concepts of the cerebellar function, and its decline associated with aging-from macrostructural, functional, histological, biochemical, and epigenetic perspectives. Several candidate hypotheses are discussed to explain the seemingly contradictory lower epigenetic age of the cerebellum relative to the rest of the brain, but also a rate of atrophy far higher than seen in other parts of the brain with the exception of hippocampus and prefrontal cortex, with both structural damage to cerebellar white matter and loss of cerebellar neurons. The cerebellum is hypothesized to create new neural scaffolds to counteract aging-related changes and maintain its performance. If sufficient informational input is provided as in simpler motor tasks, while signal noise due to white matter affections in complex, extensive cognitive networks do not allow for the construction and utilization of cerebellar internal models, leading ultimately to the failure of cerebellar feedforward processing stream.

Název v anglickém jazyce

Cerebellum - aging of the neuronal machine

Popis výsledku anglicky

This chapter provides an overview of the structure of the cerebellum, the current concepts of the cerebellar function, and its decline associated with aging-from macrostructural, functional, histological, biochemical, and epigenetic perspectives. Several candidate hypotheses are discussed to explain the seemingly contradictory lower epigenetic age of the cerebellum relative to the rest of the brain, but also a rate of atrophy far higher than seen in other parts of the brain with the exception of hippocampus and prefrontal cortex, with both structural damage to cerebellar white matter and loss of cerebellar neurons. The cerebellum is hypothesized to create new neural scaffolds to counteract aging-related changes and maintain its performance. If sufficient informational input is provided as in simpler motor tasks, while signal noise due to white matter affections in complex, extensive cognitive networks do not allow for the construction and utilization of cerebellar internal models, leading ultimately to the failure of cerebellar feedforward processing stream.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet

ISBN

978-0-12-817990-1

Počet stran výsledku

8

Strana od-do

281-288

Počet stran knihy

659

Název nakladatele

Elsevier

Místo vydání

London

Kód UT WoS kapitoly

—