Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10429306" target="_blank" >RIV/00064165:_____/22:10429306 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/21:00074953 RIV/00216224:14110/22:00124966 RIV/00216208:11110/22:10429306

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3S9a2OAlP" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3S9a2OAlP</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ipd.12847" target="_blank" >10.1111/ipd.12847</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis

Popis výsledku v původním jazyce

Background Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor CD14. Aim This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. Design A total of 590 unrelated children (307 with plaque-induced gingivitis and 283 controls, aged 13-15 years) were enrolled in this case-control study. Dental plaque was processed using a ParoCheck(R) 20 detection kit. The CD14 -260C/T (rs2569190) polymorphism was determined with the PCR-RFLP method. Results Gingivitis was detected in 64.2% of boys, but only in 35.8% of girls (P &lt; .001). Children with gingivitis had a significantly higher occurrence of dental caries (P &lt; .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P &lt; .05). Conclusions The CD14 -260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque-induced gingivitis in Czech children.

Název v anglickém jazyce

Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis

Popis výsledku anglicky

Background Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor CD14. Aim This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. Design A total of 590 unrelated children (307 with plaque-induced gingivitis and 283 controls, aged 13-15 years) were enrolled in this case-control study. Dental plaque was processed using a ParoCheck(R) 20 detection kit. The CD14 -260C/T (rs2569190) polymorphism was determined with the PCR-RFLP method. Results Gingivitis was detected in 64.2% of boys, but only in 35.8% of girls (P &lt; .001). Children with gingivitis had a significantly higher occurrence of dental caries (P &lt; .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P &lt; .05). Conclusions The CD14 -260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque-induced gingivitis in Czech children.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Paediatric Dentistry

ISSN

0960-7439

e-ISSN

1365-263X

Svazek periodika

32

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

9

Strana od-do

223-231

Kód UT WoS článku

000661667900001

EID výsledku v databázi Scopus

2-s2.0-85107983660