Symptomatic preterm infants suffer from lung function deficits, regardless of bronchopulmonary dysplasia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10447001" target="_blank" >RIV/00064165:_____/22:10447001 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/22:10447001 RIV/00216208:11110/22:10447001 RIV/00216208:11130/22:10447001

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vhVYcirPlh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vhVYcirPlh</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ppul.26144" target="_blank" >10.1002/ppul.26144</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Symptomatic preterm infants suffer from lung function deficits, regardless of bronchopulmonary dysplasia

Popis výsledku v původním jazyce

BACKGROUND: The long-term respiratory consequences for children with bronchopulmonary dysplasia (BPD) are well known. However, there is little emphasis on monitoring preterm infants without BPD. Few studies have explored the lung function status of infants with the symptoms of chronic lung disease of prematurity (CLD). OBJECTIVE: To evaluate functional lung deficits in preterm infants with CLD, and to assess the perinatal determinants of diminished lung function. METHODS: In our cross-sectional study, 132 preterm infants with symptomatic CLD underwent infant pulmonary function testing (iPFT) at a median post-term age of 0.9 years. The iPFT included bodypletysmography, compliance measurement, tidal breath analysis, and rapid thoracoabdominal compression. The relationships between the respective z scores of the iPFT parameters to perinatal characteristics, postnatal treatment, and BPD status were investigated. RESULTS: 73 patients (55.3%) were born before the 28(th) week of gestation, and 92 (69.7%) met the BPD criteria. Functional deficits were detected in 85.8%. The obstructive ventilatory pattern was more prevalent than restrictive (36.3 vs 12.4%, p &lt; 0.001). Infants with restriction had lower birth weight and required a longer duration of oxygenotherapy. In a univariate model, the lung function correlated with the duration of invasive mechanical ventilation, gestational week, and birth weight. In a general linear model, BPD status was not an additional determinant of the iPFT results. CONCLUSION: IPFT may reveal significant functional deficits in preterm infants with CLD even without BPD. The current symptoms and perinatal factors may be more important determinants of functional deficits than the BPD status itself.

Název v anglickém jazyce

Symptomatic preterm infants suffer from lung function deficits, regardless of bronchopulmonary dysplasia

Popis výsledku anglicky

BACKGROUND: The long-term respiratory consequences for children with bronchopulmonary dysplasia (BPD) are well known. However, there is little emphasis on monitoring preterm infants without BPD. Few studies have explored the lung function status of infants with the symptoms of chronic lung disease of prematurity (CLD). OBJECTIVE: To evaluate functional lung deficits in preterm infants with CLD, and to assess the perinatal determinants of diminished lung function. METHODS: In our cross-sectional study, 132 preterm infants with symptomatic CLD underwent infant pulmonary function testing (iPFT) at a median post-term age of 0.9 years. The iPFT included bodypletysmography, compliance measurement, tidal breath analysis, and rapid thoracoabdominal compression. The relationships between the respective z scores of the iPFT parameters to perinatal characteristics, postnatal treatment, and BPD status were investigated. RESULTS: 73 patients (55.3%) were born before the 28(th) week of gestation, and 92 (69.7%) met the BPD criteria. Functional deficits were detected in 85.8%. The obstructive ventilatory pattern was more prevalent than restrictive (36.3 vs 12.4%, p &lt; 0.001). Infants with restriction had lower birth weight and required a longer duration of oxygenotherapy. In a univariate model, the lung function correlated with the duration of invasive mechanical ventilation, gestational week, and birth weight. In a general linear model, BPD status was not an additional determinant of the iPFT results. CONCLUSION: IPFT may reveal significant functional deficits in preterm infants with CLD even without BPD. The current symptoms and perinatal factors may be more important determinants of functional deficits than the BPD status itself.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatric Pulmonology [online]

ISSN

1099-0496

e-ISSN

1099-0496

Svazek periodika

57

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

BD - Bangladéšská lidová republika

Počet stran výsledku

10

Strana od-do

3119-3128

Kód UT WoS článku

000860945900001

EID výsledku v databázi Scopus

2-s2.0-85138682351