Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10450837" target="_blank" >RIV/00064165:_____/22:10450837 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10450837

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=g7laEKZOZc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=g7laEKZOZc</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clim.2022.109152" target="_blank" >10.1016/j.clim.2022.109152</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study

Popis výsledku v původním jazyce

Orthopedic implants heal well without complications in most patients but fail for unclear reasons in some in-dividuals. This study determined the relevance of metal hypersensitivity in patients with failed orthopedic im-plants and those requiring orthopedic implant surgery. The study included 35 patients with failed orthopedic implants and 15 subjects scheduled for orthopedic implant surgery. The production of selected pro-inflammatory cytokines was measured in patients with failed orthopedic implants. Metal hypersensitivity was measured in all subjects using the MELISA (R) test. Of common metals in orthopedic alloys, the patients with failed orthopedic implants responded most frequently to nickel, chromium, titanium, iron, and molybdenum. Hypersensitivity to metals found in implants was measured in 40% of patients with failed implants. The study also showed that titanium exposure in patients with titanium hypersensitivity might lead to implant failure. Metal hypersensitivity testing should be offered to patients before surgery to minimize the risk of implant failure.

Název v anglickém jazyce

Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study

Popis výsledku anglicky

Orthopedic implants heal well without complications in most patients but fail for unclear reasons in some in-dividuals. This study determined the relevance of metal hypersensitivity in patients with failed orthopedic im-plants and those requiring orthopedic implant surgery. The study included 35 patients with failed orthopedic implants and 15 subjects scheduled for orthopedic implant surgery. The production of selected pro-inflammatory cytokines was measured in patients with failed orthopedic implants. Metal hypersensitivity was measured in all subjects using the MELISA (R) test. Of common metals in orthopedic alloys, the patients with failed orthopedic implants responded most frequently to nickel, chromium, titanium, iron, and molybdenum. Hypersensitivity to metals found in implants was measured in 40% of patients with failed implants. The study also showed that titanium exposure in patients with titanium hypersensitivity might lead to implant failure. Metal hypersensitivity testing should be offered to patients before surgery to minimize the risk of implant failure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

<a href="/cs/project/NV19-08-00070" target="_blank" >NV19-08-00070: Využití lymfocytů hypersenzitivních pacientů pro preklinické testování pokročilých materiálů na bázi titanu modifikovaných iontovým svazkem</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Immunology

ISSN

1521-6616

e-ISSN

1521-7035

Svazek periodika

245

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

109152

Kód UT WoS článku

000884227800018

EID výsledku v databázi Scopus

2-s2.0-85140257574