4DryField vs. hyalobarrier gel for preventing the recurrence of intrauterine adhesions – a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10482622" target="_blank" >RIV/00064165:_____/25:10482622 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10482622

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TO9D2L-xMt" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TO9D2L-xMt</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/13645706.2024.2351829" target="_blank" >10.1080/13645706.2024.2351829</a>

Jazyk výsledku

angličtina

Název v původním jazyce

4DryField vs. hyalobarrier gel for preventing the recurrence of intrauterine adhesions – a pilot study

Popis výsledku v původním jazyce

Introduction: This was a single-center pilot study that sought to describe an innovative use of 4DryField(R) PH (premix) for preventing the recurrence of intrauterine adhesions (IUAs) after hysteroscopic adhesiolysis in patients with Asherman&apos;s syndrome (AS). Material and methods: Twenty-three patients with AS were enrolled and 20 were randomized (1:1 ratio) to intrauterine application of 4DryField(R) PH (n = 10) or Hyalobarrier(R) gel (n = 10) in a single-blind manner. We evaluated IUAs (American Fertility Society [AFS] score) during initial hysteroscopy and second-look hysteroscopy one month later. Patients completed a follow-up symptoms questionnaire three and reproductive outcomes questionnaire six months later. Results: The demographic and clinical characteristics, as well as severity of IUAs, were comparable in both groups. The mean initial AFS score was 9 and 8.5 in the 4DryField(R) PH and Hyalobarrier(R) gel groups, respectively (p = .476). There were no between-group differences in AFS progress (5.9 vs. 5.6, p = .675), need for secondary adhesiolysis (7 vs. 7 patients, p = 1), and the follow-up outcomes. Conclusion: 4DryField(R) PH could be a promising antiadhesive agent for preventing the recurrence of IUAs, showing similar effectiveness and safety to Hyalobarrier(R) gel. Our findings warrant prospective validation in a larger clinical trial.

Název v anglickém jazyce

4DryField vs. hyalobarrier gel for preventing the recurrence of intrauterine adhesions – a pilot study

Popis výsledku anglicky

Introduction: This was a single-center pilot study that sought to describe an innovative use of 4DryField(R) PH (premix) for preventing the recurrence of intrauterine adhesions (IUAs) after hysteroscopic adhesiolysis in patients with Asherman&apos;s syndrome (AS). Material and methods: Twenty-three patients with AS were enrolled and 20 were randomized (1:1 ratio) to intrauterine application of 4DryField(R) PH (n = 10) or Hyalobarrier(R) gel (n = 10) in a single-blind manner. We evaluated IUAs (American Fertility Society [AFS] score) during initial hysteroscopy and second-look hysteroscopy one month later. Patients completed a follow-up symptoms questionnaire three and reproductive outcomes questionnaire six months later. Results: The demographic and clinical characteristics, as well as severity of IUAs, were comparable in both groups. The mean initial AFS score was 9 and 8.5 in the 4DryField(R) PH and Hyalobarrier(R) gel groups, respectively (p = .476). There were no between-group differences in AFS progress (5.9 vs. 5.6, p = .675), need for secondary adhesiolysis (7 vs. 7 patients, p = 1), and the follow-up outcomes. Conclusion: 4DryField(R) PH could be a promising antiadhesive agent for preventing the recurrence of IUAs, showing similar effectiveness and safety to Hyalobarrier(R) gel. Our findings warrant prospective validation in a larger clinical trial.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Minimally Invasive Therapy and Allied Technologies

ISSN

1364-5706

e-ISSN

1365-2931

Svazek periodika

34

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NO - Norské království

Počet stran výsledku

7

Strana od-do

71-77

Kód UT WoS článku

001228624900001

EID výsledku v databázi Scopus

2-s2.0-85193717887