Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10495450" target="_blank" >RIV/00064165:_____/25:10495450 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10495450

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Uu-W-kuNnI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Uu-W-kuNnI</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sleep.2025.02.019" target="_blank" >10.1016/j.sleep.2025.02.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia

Popis výsledku v původním jazyce

Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study examines HRQoL of NT1, NT2, IH, and healthy controls (HC) and assesses the HRQoL associates in these diseases. Patients and methods: 117 adults (64 NT1, 22 NT2, 31 IH; 61.5 % women; 38.3 +- 12.0 years; 71.8 % treated) and 41 HC (53.7 % women; 35.9 +- 9.6 years) completed questionnaires assessing sleepiness, fatigue, symptoms severity, sleep inertia, depressive and anxiety symptoms, HRQoL, and underwent a semi-structured interview. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests, Spearman&apos;s correlation coefficient, and regression analysis. Results: HRQoL of NT1, NT2, and IH, separately, was poorer compared to HC (p &lt; 0.001). According to the 36-Item Short Form Health Survey, the mental HRQoL was more impaired in NT2 and IH than NT1 (p &lt; 0.05) in association with more pronounced depressive symptoms (p &lt; 0.01; p &lt; 0.05, respectively) and sleep inertia (p &lt; 0.01; p &lt; 0.01, respectively). Psychiatric disorders were more prevalent in NT2 and IH versus NT1 (p &lt; 0.05). Conclusion: HRQoL is reduced in NT1, NT2, and IH, with this reduction being more pronounced in NT2 and IH. Poor mental HRQoL of NT2 and IH was associated both with the severity of depressive symptoms and more intense sleep inertia.

Název v anglickém jazyce

Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia

Popis výsledku anglicky

Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study examines HRQoL of NT1, NT2, IH, and healthy controls (HC) and assesses the HRQoL associates in these diseases. Patients and methods: 117 adults (64 NT1, 22 NT2, 31 IH; 61.5 % women; 38.3 +- 12.0 years; 71.8 % treated) and 41 HC (53.7 % women; 35.9 +- 9.6 years) completed questionnaires assessing sleepiness, fatigue, symptoms severity, sleep inertia, depressive and anxiety symptoms, HRQoL, and underwent a semi-structured interview. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests, Spearman&apos;s correlation coefficient, and regression analysis. Results: HRQoL of NT1, NT2, and IH, separately, was poorer compared to HC (p &lt; 0.001). According to the 36-Item Short Form Health Survey, the mental HRQoL was more impaired in NT2 and IH than NT1 (p &lt; 0.05) in association with more pronounced depressive symptoms (p &lt; 0.01; p &lt; 0.05, respectively) and sleep inertia (p &lt; 0.01; p &lt; 0.01, respectively). Psychiatric disorders were more prevalent in NT2 and IH versus NT1 (p &lt; 0.05). Conclusion: HRQoL is reduced in NT1, NT2, and IH, with this reduction being more pronounced in NT2 and IH. Poor mental HRQoL of NT2 and IH was associated both with the severity of depressive symptoms and more intense sleep inertia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30300 - Health sciences

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sleep Medicine

ISSN

1389-9457

e-ISSN

1878-5506

Svazek periodika

129

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

31-39

Kód UT WoS článku

001430017700001

EID výsledku v databázi Scopus

2-s2.0-85217893476