Evidence of an excellent international cooperation in the management of chronic thromboembolic pulmonary hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10501939" target="_blank" >RIV/00064165:_____/25:10501939 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10501939

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rfTOvEBeD4" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rfTOvEBeD4</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Evidence of an excellent international cooperation in the management of chronic thromboembolic pulmonary hypertension

Popis výsledku v původním jazyce

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease requiring centralized management in specialized centres. Balloon pulmonary angioplasty (BPA) is a treatment option for patients ineligible for pulmonary endarterectomy (PEA) or with residual pulmonary hypertension after PEA. Smaller countries collaborate with larger expert centres to ensure comprehensive care. Methods: This retrospective study assessed international collaboration in CTEPH interventional treatment based on data from 43 BPA procedures performed on 13 patients. Results: Significant improvements were observed between baseline and post-BPA parameters. WHO functional class improved from 23% to 77% in class I/II (p = 0.019), and the 6-minute walk distance increased by 191 meters (p = 0.009). Mean pulmonary artery pressure decreased by 27.9% (p &lt; 0.001), and pulmonary vascular resistance was reduced by 35.3% (p = 0.025). Echocardiographic follow-ups demonstrated enhanced right ventricular function, alongside a reduction in the tricuspid regurgitation gradient by an average of 31 mmHg (40.2%; p &lt; 0.001). A total of 4 non-fatal complications (9.3% of procedures) were observed, with no fatal complications reported. Conclusion: This study confirmed significant clinical and hemodynamic improvements following BPA, with outcomes comparable to those achieved in large expert centres. The rate of procedure-related complications was acceptable, highlighting the potential for successful international collaboration in CTEPH management (Tab. 2, Fig. 2, Ref. 18).

Název v anglickém jazyce

Evidence of an excellent international cooperation in the management of chronic thromboembolic pulmonary hypertension

Popis výsledku anglicky

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease requiring centralized management in specialized centres. Balloon pulmonary angioplasty (BPA) is a treatment option for patients ineligible for pulmonary endarterectomy (PEA) or with residual pulmonary hypertension after PEA. Smaller countries collaborate with larger expert centres to ensure comprehensive care. Methods: This retrospective study assessed international collaboration in CTEPH interventional treatment based on data from 43 BPA procedures performed on 13 patients. Results: Significant improvements were observed between baseline and post-BPA parameters. WHO functional class improved from 23% to 77% in class I/II (p = 0.019), and the 6-minute walk distance increased by 191 meters (p = 0.009). Mean pulmonary artery pressure decreased by 27.9% (p &lt; 0.001), and pulmonary vascular resistance was reduced by 35.3% (p = 0.025). Echocardiographic follow-ups demonstrated enhanced right ventricular function, alongside a reduction in the tricuspid regurgitation gradient by an average of 31 mmHg (40.2%; p &lt; 0.001). A total of 4 non-fatal complications (9.3% of procedures) were observed, with no fatal complications reported. Conclusion: This study confirmed significant clinical and hemodynamic improvements following BPA, with outcomes comparable to those achieved in large expert centres. The rate of procedure-related complications was acceptable, highlighting the potential for successful international collaboration in CTEPH management (Tab. 2, Fig. 2, Ref. 18).

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lekarsky Obzor

ISSN

0457-4214

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

8

Strana od-do

124-131

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-105000419277