Disease course after pregnancy in women with progressive multiple sclerosis symptoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10503569" target="_blank" >RIV/00064165:_____/25:10503569 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10503569

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3CPIZlkuJd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3CPIZlkuJd</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/13524585251368248" target="_blank" >10.1177/13524585251368248</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Disease course after pregnancy in women with progressive multiple sclerosis symptoms

Popis výsledku v původním jazyce

Background: The impact of pregnancy on disease outcomes has not been characterised in women with progressive multiple sclerosis (MS) phenotypes. This study aimed to describe the clinical characteristics and disease course of women who experienced a pregnancy after a diagnosis of primary progressive MS (PPMS) or secondary progressive MS (SPMS).Methods: This multicentre observational cohort study utilised data from the international MSBase Registry extracted on 2 June 2024. Expanded Disability Status Scale (EDSS) scores of women with progressive MS were assessed up to 10 years postpartum and compared to those of propensity score-matched women with progressive MS without a pregnancy history.Results: In total, 138 women with 164 pregnancies were included in the study, comprising 75 women with PPMS and 63 with SPMS. Of these, 24 women with PPMS and 47 with SPMS had longitudinal peri-pregnancy EDSS assessments and were included in the analysis of disability scores. A history of pregnancy was not associated with a significant difference in long-term disability trajectories in women with either PPMS (estimate = -0.02; 95% confidence interval (CI) = -0.07 to 0.04) or SPMS (estimate = 0.00; 95% CI = -0.02 to 0.03).Conclusion: A history of pregnancy is not associated with a significant difference in long-term disability in women with progressive MS symptoms.

Název v anglickém jazyce

Disease course after pregnancy in women with progressive multiple sclerosis symptoms

Popis výsledku anglicky

Background: The impact of pregnancy on disease outcomes has not been characterised in women with progressive multiple sclerosis (MS) phenotypes. This study aimed to describe the clinical characteristics and disease course of women who experienced a pregnancy after a diagnosis of primary progressive MS (PPMS) or secondary progressive MS (SPMS).Methods: This multicentre observational cohort study utilised data from the international MSBase Registry extracted on 2 June 2024. Expanded Disability Status Scale (EDSS) scores of women with progressive MS were assessed up to 10 years postpartum and compared to those of propensity score-matched women with progressive MS without a pregnancy history.Results: In total, 138 women with 164 pregnancies were included in the study, comprising 75 women with PPMS and 63 with SPMS. Of these, 24 women with PPMS and 47 with SPMS had longitudinal peri-pregnancy EDSS assessments and were included in the analysis of disability scores. A history of pregnancy was not associated with a significant difference in long-term disability trajectories in women with either PPMS (estimate = -0.02; 95% confidence interval (CI) = -0.07 to 0.04) or SPMS (estimate = 0.00; 95% CI = -0.02 to 0.03).Conclusion: A history of pregnancy is not associated with a significant difference in long-term disability in women with progressive MS symptoms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Multiple Sclerosis Journal

ISSN

1352-4585

e-ISSN

1477-0970

Svazek periodika

31

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

1439-1451

Kód UT WoS článku

001574809600001

EID výsledku v databázi Scopus

2-s2.0-105019625123