Untreated incomplete ALCAPA in an adult resulting in mitral regurgitation and reduced left ventricular ejection fraction: case report

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10504255" target="_blank" >RIV/00064165:_____/25:10504255 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10504255

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8zV30NKpG7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8zV30NKpG7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ehjcr/ytaf482" target="_blank" >10.1093/ehjcr/ytaf482</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Untreated incomplete ALCAPA in an adult resulting in mitral regurgitation and reduced left ventricular ejection fraction: case report

Popis výsledku v původním jazyce

BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital malformation, with an incidence ranging from 1 in 300 000 to 1 in 30 000 live births. Incomplete ALCAPA is defined as an abnormal origin of either the left anterior descending coronary artery (LAD) or the circumflex artery from the aorta. It may also present as ALCAPA with duplication of one of these arteries due to an additional branch arising from the aorta. CASE SUMMARY: The case report presents a man diagnosed with dilated cardiomyopathy at the age of 29. Despite repeated echocardiographic examinations, the diagnosis of incomplete ALCAPA (additional LAD arising from the aorta) as the aetiology of the dilated cardiomyopathy with reduced left ventricular ejection fraction and severe mitral regurgitation was only established at age 57. The patient underwent surgical correction of the ALCAPA and mitral valve repair. Despite optimal surgical intervention, only minimal postoperative improvement in the left ventricular ejection fraction was observed. DISCUSSION: According to guidelines, computed tomography angiography is the most effective diagnostic method for anomalous origin of coronary artery from the pulmonary artery (ACAPA). Due to ACAPA&apos;s extreme rarity, standard indications for surgical intervention in incomplete ALCAPA are not established. Surgical correction appears most suitable for symptomatic patients. It should also be considered for asymptomatic patients with ventricular dysfunction or myocardial ischaemia caused by the coronary anomaly.

Název v anglickém jazyce

Untreated incomplete ALCAPA in an adult resulting in mitral regurgitation and reduced left ventricular ejection fraction: case report

Popis výsledku anglicky

BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital malformation, with an incidence ranging from 1 in 300 000 to 1 in 30 000 live births. Incomplete ALCAPA is defined as an abnormal origin of either the left anterior descending coronary artery (LAD) or the circumflex artery from the aorta. It may also present as ALCAPA with duplication of one of these arteries due to an additional branch arising from the aorta. CASE SUMMARY: The case report presents a man diagnosed with dilated cardiomyopathy at the age of 29. Despite repeated echocardiographic examinations, the diagnosis of incomplete ALCAPA (additional LAD arising from the aorta) as the aetiology of the dilated cardiomyopathy with reduced left ventricular ejection fraction and severe mitral regurgitation was only established at age 57. The patient underwent surgical correction of the ALCAPA and mitral valve repair. Despite optimal surgical intervention, only minimal postoperative improvement in the left ventricular ejection fraction was observed. DISCUSSION: According to guidelines, computed tomography angiography is the most effective diagnostic method for anomalous origin of coronary artery from the pulmonary artery (ACAPA). Due to ACAPA&apos;s extreme rarity, standard indications for surgical intervention in incomplete ALCAPA are not established. Surgical correction appears most suitable for symptomatic patients. It should also be considered for asymptomatic patients with ventricular dysfunction or myocardial ischaemia caused by the coronary anomaly.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Heart Journal - Case Reports

ISSN

2514-2119

e-ISSN

2514-2119

Svazek periodika

9

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

ytaf482

Kód UT WoS článku

001593826600001

EID výsledku v databázi Scopus

2-s2.0-105019371378