The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F14%3AN0000041" target="_blank" >RIV/00064173:_____/14:N0000041 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/sji.12193" target="_blank" >http://dx.doi.org/10.1111/sji.12193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.12193" target="_blank" >10.1111/sji.12193</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

Popis výsledku v původním jazyce

Mucosal associated invariant T (MAIT) cells are innate-like T cells comprising up to 10% of the peripheral blood T cells in humans. During ontogeny, MAIT cells can first be detected in the cord blood in low amounts, but rise steadily after birth. In this population-based study, we show that their counts continue to increase, reaching maximal levels (4.5% of CD3+ cells, 65 cells/μl) in the third and fourth decenniums. At this age, the amounts of MAIT cells exhibit the highest inter-individual variability. The values then dramatically decline; subjects 80 years old and older have on average 10 times less MAIT cells, both absolutely and as a percentage among CD3+ T cells, than subjects in fertile age. The senescence of MAIT cells is associated with decreased CD8/double negative (DN) ratio. Finally, we observed significantly higher amounts of MAIT cells in females of reproductive age than in males of the same age. Our data suggests that further studies aimed at elucidating a role of MAIT cells in human pathologies must recruit age- and gender- matched controls.

Název v anglickém jazyce

The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

Popis výsledku anglicky

Mucosal associated invariant T (MAIT) cells are innate-like T cells comprising up to 10% of the peripheral blood T cells in humans. During ontogeny, MAIT cells can first be detected in the cord blood in low amounts, but rise steadily after birth. In this population-based study, we show that their counts continue to increase, reaching maximal levels (4.5% of CD3+ cells, 65 cells/μl) in the third and fourth decenniums. At this age, the amounts of MAIT cells exhibit the highest inter-individual variability. The values then dramatically decline; subjects 80 years old and older have on average 10 times less MAIT cells, both absolutely and as a percentage among CD3+ T cells, than subjects in fertile age. The senescence of MAIT cells is associated with decreased CD8/double negative (DN) ratio. Finally, we observed significantly higher amounts of MAIT cells in females of reproductive age than in males of the same age. Our data suggests that further studies aimed at elucidating a role of MAIT cells in human pathologies must recruit age- and gender- matched controls.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scandinavian Journal of Immunology

ISSN

0300-9475

e-ISSN

1365-3083

Svazek periodika

80

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

271-275

Kód UT WoS článku

000342687500004

EID výsledku v databázi Scopus

2-s2.0-84907830208