Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000140" target="_blank" >RIV/00064173:_____/16:N0000140 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/16:10330674 RIV/00216208:11120/16:43911994 RIV/00669806:_____/16:10330674

Výsledek na webu

<a href="http://dx.doi.org/10.1111/his.13026" target="_blank" >http://dx.doi.org/10.1111/his.13026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/his.13026" target="_blank" >10.1111/his.13026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

Popis výsledku v původním jazyce

BACKGROUND: Littoral cell angioma (LCA) is a rare primary splenic tumor frequently associated with internal malignancies. Immunohistochemistry (IHC) can prove a distinct hybrid endothelial/histiocytic phenotype of littoral cells and is a helpful adjunct to render the correct diagnosis. We present a series of 25 LCA with an emphasis on the frequent association of the neoplasm with visceral malignancies and provide a detailed immunohistochemical analysis by employing new markers. DESIGN: All 25 cases with available tissue blocks were immunohistochemically stained for endothelial and histiocytic markers. Clinical data and follow-up were retrieved from respective institutions. RESULTS: The tumors were obtained from 16 males and 9 females, whose age ranged from 32 to 86 years (mean 56.2 yrs). Clinical information was available for 24/25 patients and follow-up for 11/25 patients (range 2-19 years; mean 11.6). Immunohistochemically, all cases were positive for LYVE 1, FVIII, Fli-1, VEGFR 2, VEGFR 3, Claudin-5, ERG, LMO2, CD31, CD163, Lysozyme, and CD4, but were negative for D2-40, CD8 and Factor XIIIa. 15/25 cases were associated with various malignancies including epithelial, mesenchymal and hematological tumors. CONCLUSIONS: The cohort of 25 patients is the largest series of LCA published to date. Using antibodies to recently introduced endothelial markers we have expanded the immunoprofile of LCA. We have further highlighted the clinical significance of LCA, inasmuch as more than half of the patients in this study also harbored a co-existent visceral malignancy. Therefore, we conclude that the finding of splenic LCA mandates a thorough clinical evaluation for a concomitant malignancy.

Název v anglickém jazyce

Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

Popis výsledku anglicky

BACKGROUND: Littoral cell angioma (LCA) is a rare primary splenic tumor frequently associated with internal malignancies. Immunohistochemistry (IHC) can prove a distinct hybrid endothelial/histiocytic phenotype of littoral cells and is a helpful adjunct to render the correct diagnosis. We present a series of 25 LCA with an emphasis on the frequent association of the neoplasm with visceral malignancies and provide a detailed immunohistochemical analysis by employing new markers. DESIGN: All 25 cases with available tissue blocks were immunohistochemically stained for endothelial and histiocytic markers. Clinical data and follow-up were retrieved from respective institutions. RESULTS: The tumors were obtained from 16 males and 9 females, whose age ranged from 32 to 86 years (mean 56.2 yrs). Clinical information was available for 24/25 patients and follow-up for 11/25 patients (range 2-19 years; mean 11.6). Immunohistochemically, all cases were positive for LYVE 1, FVIII, Fli-1, VEGFR 2, VEGFR 3, Claudin-5, ERG, LMO2, CD31, CD163, Lysozyme, and CD4, but were negative for D2-40, CD8 and Factor XIIIa. 15/25 cases were associated with various malignancies including epithelial, mesenchymal and hematological tumors. CONCLUSIONS: The cohort of 25 patients is the largest series of LCA published to date. Using antibodies to recently introduced endothelial markers we have expanded the immunoprofile of LCA. We have further highlighted the clinical significance of LCA, inasmuch as more than half of the patients in this study also harbored a co-existent visceral malignancy. Therefore, we conclude that the finding of splenic LCA mandates a thorough clinical evaluation for a concomitant malignancy.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Histopathology

ISSN

0309-0167

e-ISSN

—

Svazek periodika

69

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

762-774

Kód UT WoS článku

000388300800005

EID výsledku v databázi Scopus

2-s2.0-84982286043