Quantitative changes of melanoma-associated antigens as a biomarker for targeted therapy response
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000192" target="_blank" >RIV/00064173:_____/16:N0000192 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11120/16:43911791
Výsledek na webu
<a href="http://dx.doi.org/10.1111/exd.12947" target="_blank" >http://dx.doi.org/10.1111/exd.12947</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/exd.12947" target="_blank" >10.1111/exd.12947</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Quantitative changes of melanoma-associated antigens as a biomarker for targeted therapy response
Popis výsledku v původním jazyce
Novel treatment modalities significantly improve survival of patients with metastatic melanoma. However, targeted therapy with BRAF inhibitors is connected with development of drug resistance within 6-9 months. Biomarkers for prediction of treatment response and failure are indispensably needed. Here we determine the prognostic impact of multimarker detection of circulating melanoma cells in patients with metastatic melanoma treated with vemurafenib. In this prospective study, 51 patients with metastatic melanoma in unresectable stage III and metastatic stage IV treated with vemurafenib were included. The real-time RT-PCR values of 5 melanoma markers Melan-A, gp100, MAGE-3, MIA, and ABCB5 prior to the treatment and within the therapy were compared to the data collected after the melanoma surgery. Longitudinal follow-up of melanoma markers in patients treated with vemurafenib correlates with prognostic parameters such as progression free survival and overall survival. A rapid drop of markers > 50 % within 4 weeks of treatment was associated with long-term response to therapy. Elevation of tumor markers precedes clinical progression and may give an early warning of development of drug resistance. Melanoma circulating cells hold the potential as a prognostic, predictive, and pharmacodynamic biomarker during the treatment with vemurafenib.
Název v anglickém jazyce
Quantitative changes of melanoma-associated antigens as a biomarker for targeted therapy response
Popis výsledku anglicky
Novel treatment modalities significantly improve survival of patients with metastatic melanoma. However, targeted therapy with BRAF inhibitors is connected with development of drug resistance within 6-9 months. Biomarkers for prediction of treatment response and failure are indispensably needed. Here we determine the prognostic impact of multimarker detection of circulating melanoma cells in patients with metastatic melanoma treated with vemurafenib. In this prospective study, 51 patients with metastatic melanoma in unresectable stage III and metastatic stage IV treated with vemurafenib were included. The real-time RT-PCR values of 5 melanoma markers Melan-A, gp100, MAGE-3, MIA, and ABCB5 prior to the treatment and within the therapy were compared to the data collected after the melanoma surgery. Longitudinal follow-up of melanoma markers in patients treated with vemurafenib correlates with prognostic parameters such as progression free survival and overall survival. A rapid drop of markers > 50 % within 4 weeks of treatment was associated with long-term response to therapy. Elevation of tumor markers precedes clinical progression and may give an early warning of development of drug resistance. Melanoma circulating cells hold the potential as a prognostic, predictive, and pharmacodynamic biomarker during the treatment with vemurafenib.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FO - Dermatovenerologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/NT14440" target="_blank" >NT14440: Detekce cirkulujících melanomových buněk jako marker úspěšnosti imunoterapie</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Experimental Dermatology
ISSN
0906-6705
e-ISSN
—
Svazek periodika
25
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
3
Strana od-do
727-729
Kód UT WoS článku
000385353200001
EID výsledku v databázi Scopus
2-s2.0-84983512690