Prolonged repolarization in atrial septal defect: An example of mechanoelectrical feedback due to right ventricular volume overload

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000206" target="_blank" >RIV/00064173:_____/16:N0000206 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10324091 RIV/00216208:11120/16:43911611 RIV/00064203:_____/16:10324091

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.hrthm.2016.01.032" target="_blank" >http://dx.doi.org/10.1016/j.hrthm.2016.01.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.hrthm.2016.01.032" target="_blank" >10.1016/j.hrthm.2016.01.032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prolonged repolarization in atrial septal defect: An example of mechanoelectrical feedback due to right ventricular volume overload

Popis výsledku v původním jazyce

BACKGROUND: Prolonged corrected QT (QTc) intervals are frequently observed in children before atrial septal defect (ASD) closure in our department. OBJECTIVE: The aim of the study was to assess the effect of long-term right ventricular volume overload on repolarization. METHODS: QRS, QT, and JT intervals were measured manually in leads II and V5 of a standard 12-lead electrocardiogram in 45 children with an isolated ASD a day before and at least 6 months after ASD closure. QT intervals were corrected for heart rate using the Bazett, Fridericia, Framingham, and Hodges formulas. Each QTc interval calculated using the Bazett formula was compared to sex- and age-matched normal values. RESULTS: Individual QTc intervals shortened significantly (P < .001) using all correction formulas, whereas the QRS duration did not change. The prevalence of prolonged QTc interval decreased from 22.2% to 2.2% after shunt closure (P = .007). CONCLUSION: The QTc interval shortens significantly after the closure of a hemodynamically relevant ASD in childhood. This phenomenon is independent of the used QT correction formula and may reflect a mechanoelectrical feedback associated with right ventricular volume overload.

Název v anglickém jazyce

Prolonged repolarization in atrial septal defect: An example of mechanoelectrical feedback due to right ventricular volume overload

Popis výsledku anglicky

BACKGROUND: Prolonged corrected QT (QTc) intervals are frequently observed in children before atrial septal defect (ASD) closure in our department. OBJECTIVE: The aim of the study was to assess the effect of long-term right ventricular volume overload on repolarization. METHODS: QRS, QT, and JT intervals were measured manually in leads II and V5 of a standard 12-lead electrocardiogram in 45 children with an isolated ASD a day before and at least 6 months after ASD closure. QT intervals were corrected for heart rate using the Bazett, Fridericia, Framingham, and Hodges formulas. Each QTc interval calculated using the Bazett formula was compared to sex- and age-matched normal values. RESULTS: Individual QTc intervals shortened significantly (P < .001) using all correction formulas, whereas the QRS duration did not change. The prevalence of prolonged QTc interval decreased from 22.2% to 2.2% after shunt closure (P = .007). CONCLUSION: The QTc interval shortens significantly after the closure of a hemodynamically relevant ASD in childhood. This phenomenon is independent of the used QT correction formula and may reflect a mechanoelectrical feedback associated with right ventricular volume overload.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart Rhythm

ISSN

1547-5271

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1303-1308

Kód UT WoS článku

000376334800018

EID výsledku v databázi Scopus

2-s2.0-84960153286