PAR2: The Cornerstone of Pancreatic Diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43924435" target="_blank" >RIV/00064173:_____/22:43924435 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11120/22:43924435 RIV/00064190:_____/22:N0000013
Výsledek na webu
<a href="https://doi.org/10.33549/physiolres.934931" target="_blank" >https://doi.org/10.33549/physiolres.934931</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934931" target="_blank" >10.33549/physiolres.934931</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
PAR2: The Cornerstone of Pancreatic Diseases
Popis výsledku v původním jazyce
It has been 30 years since the first member of the protease -activated receptor (PAR) family was discovered. This was followed by the discovery of three other receptors, including PAR2. PAR2 is a G protein-coupled receptor activated by trypsin site-specific proteolysis. The process starts with serine proteases acting between arginine and serine, creating an N-terminus that functions as a tethered ligand that binds, after a conformational change, to the second extracellular loop of the receptor, leading to activation of G-proteins. The physiological and pathological functions of this ubiquitous receptor are still elusive. This review focuses on PAR2 activation and its distribution under physiological and pathological conditions, with a particular focus on the pancreas, a significant producer of trypsin, which is the prototype activator of the receptor. The role in acute or chronic pancreatitis, pancreatic cancer, and diabetes mellitus will be highlighted.
Název v anglickém jazyce
PAR2: The Cornerstone of Pancreatic Diseases
Popis výsledku anglicky
It has been 30 years since the first member of the protease -activated receptor (PAR) family was discovered. This was followed by the discovery of three other receptors, including PAR2. PAR2 is a G protein-coupled receptor activated by trypsin site-specific proteolysis. The process starts with serine proteases acting between arginine and serine, creating an N-terminus that functions as a tethered ligand that binds, after a conformational change, to the second extracellular loop of the receptor, leading to activation of G-proteins. The physiological and pathological functions of this ubiquitous receptor are still elusive. This review focuses on PAR2 activation and its distribution under physiological and pathological conditions, with a particular focus on the pancreas, a significant producer of trypsin, which is the prototype activator of the receptor. The role in acute or chronic pancreatitis, pancreatic cancer, and diabetes mellitus will be highlighted.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30109 - Pathology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Svazek periodika
71
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
14
Strana od-do
583-596
Kód UT WoS článku
000890049600001
EID výsledku v databázi Scopus
2-s2.0-85149879097