Feasibility and safety of left bundle branch area pacing-cardiac resynchronization therapy in elderly patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F23%3A43923058" target="_blank" >RIV/00064173:_____/23:43923058 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/23:43923058 RIV/00216208:11150/23:10441801 RIV/00179906:_____/23:10441801

Výsledek na webu

<a href="https://doi.org/10.1007/s10840-022-01174-4" target="_blank" >https://doi.org/10.1007/s10840-022-01174-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10840-022-01174-4" target="_blank" >10.1007/s10840-022-01174-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Feasibility and safety of left bundle branch area pacing-cardiac resynchronization therapy in elderly patients

Popis výsledku v původním jazyce

BACKGROUND: Left bundle branch area pacing (LBBAP) is an emerging technique to achieve cardiac resynchronization therapy (CRT), but its feasibility and safety in elderly patients with heart failure with reduced ejection fraction and left bundle branch block is hardly investigated. METHODS: We enrolled consecutive patients with an indication for CRT comparing pacing parameters and complication rates of LBBAP-CRT in elderly patients (&gt;= 75 years) versus younger patients (&lt; 75 years) over a 6-month follow-up. RESULTS: LBBAP was successful in 55/60 enrolled patients (92%), among which 25(45%) were elderly. In both groups, LBBAP significantly reduced the QRS duration (elderly group: 168 +- 15 ms to 136 +- 12 ms, p &lt; 0.0001; younger group: 166 +- 14 ms to 134 +- 11 ms, p &lt; 0.0001) and improved LVEF (elderly group: 28 +- 5% to 40 +- 7%, p &lt; 0.0001; younger group: 29 +- 5% to 41 +- 8%, p &lt; 0.0001). The pacing threshold was 0.9 +- 0.8 V in the elderly group vs. 0.7 +- 0.5 V in the younger group (p = 0.350). The R wave was 9.5 +- 3.9 mV in elderly patients vs. 10.7 +- 2.7 mV in younger patients (p = 0.341). The fluoroscopic (elderly: 13 +- 7 min vs. younger: 11 +- 7 min, p = 0.153) and procedural time (elderly: 80 +- 20 min vs. younger: 78 +- 16 min, p = 0.749) were comparable between groups. Lead dislodgement occurred in 2(4%) patients, 1 in each group (p = 1.000). Intraprocedural septal perforation occurred in three patients (5%), 2(8%) in the elderly group (p = 0.585). One patient (2%) in the elderly group had a pocket infection. CONCLUSIONS: LBBAP is a feasible and safe technique for delivering physiological pacing in elderly patients who are candidates for CRT with suitable pacing parameters and low complication rates.

Název v anglickém jazyce

Feasibility and safety of left bundle branch area pacing-cardiac resynchronization therapy in elderly patients

Popis výsledku anglicky

BACKGROUND: Left bundle branch area pacing (LBBAP) is an emerging technique to achieve cardiac resynchronization therapy (CRT), but its feasibility and safety in elderly patients with heart failure with reduced ejection fraction and left bundle branch block is hardly investigated. METHODS: We enrolled consecutive patients with an indication for CRT comparing pacing parameters and complication rates of LBBAP-CRT in elderly patients (&gt;= 75 years) versus younger patients (&lt; 75 years) over a 6-month follow-up. RESULTS: LBBAP was successful in 55/60 enrolled patients (92%), among which 25(45%) were elderly. In both groups, LBBAP significantly reduced the QRS duration (elderly group: 168 +- 15 ms to 136 +- 12 ms, p &lt; 0.0001; younger group: 166 +- 14 ms to 134 +- 11 ms, p &lt; 0.0001) and improved LVEF (elderly group: 28 +- 5% to 40 +- 7%, p &lt; 0.0001; younger group: 29 +- 5% to 41 +- 8%, p &lt; 0.0001). The pacing threshold was 0.9 +- 0.8 V in the elderly group vs. 0.7 +- 0.5 V in the younger group (p = 0.350). The R wave was 9.5 +- 3.9 mV in elderly patients vs. 10.7 +- 2.7 mV in younger patients (p = 0.341). The fluoroscopic (elderly: 13 +- 7 min vs. younger: 11 +- 7 min, p = 0.153) and procedural time (elderly: 80 +- 20 min vs. younger: 78 +- 16 min, p = 0.749) were comparable between groups. Lead dislodgement occurred in 2(4%) patients, 1 in each group (p = 1.000). Intraprocedural septal perforation occurred in three patients (5%), 2(8%) in the elderly group (p = 0.585). One patient (2%) in the elderly group had a pocket infection. CONCLUSIONS: LBBAP is a feasible and safe technique for delivering physiological pacing in elderly patients who are candidates for CRT with suitable pacing parameters and low complication rates.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Interventional Cardiac Electrophysiology

ISSN

1383-875X

e-ISSN

1572-8595

Svazek periodika

66

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

311-321

Kód UT WoS článku

000766408000001

EID výsledku v databázi Scopus

2-s2.0-85126010256