Refractive Outcome After Corneal Lenticule Implantation Ex Vivo Non-Human Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F23%3A43925327" target="_blank" >RIV/00064173:_____/23:43925327 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/23:43925327

Výsledek na webu

<a href="https://doi.org/10.1080/02713683.2023.2192447" target="_blank" >https://doi.org/10.1080/02713683.2023.2192447</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/02713683.2023.2192447" target="_blank" >10.1080/02713683.2023.2192447</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Refractive Outcome After Corneal Lenticule Implantation Ex Vivo Non-Human Study

Popis výsledku v původním jazyce

PURPOSE: To evaluate changes in corneal refractive parameters after implantation of a stromal lenticule of different thickness. We assume that the refractive outcome depends on the optical power of the used lenticule. METHODS: We conducted an ex-vivo non-human study on 33 normotonic porcine eyeballs divided into two groups, for 4D and 8D human lenticule implantation. Corneal stromal lenticules were obtained as a by-product from a laser procedure ReLEx SMILE. We evaluated corneal refractive parameters measured on Oculus Pentacam(C) device before and immediately after the intrastromal lenticule implantation. RESULTS: There was no statistically significant difference in corneal refractive parameters between the eyeball groups before lenticule implantation. In both groups, the intrastromal implantation in the depth of 300um led to a significant increase of central corneal pachymetry and corneal anterior steepening. In the 4D group the average central corneal pachymetry increased from 903 +- 124.59 to 1230 +- 148.99 (p = 0.0022) and in 8D group from 733.35 +- 69.60 to 1109 +- 161.64 (p = 0.0008). Induced changes in other studied parameters were not statistically significant, Kmax changed from 45.57 +- 2.78 to 72.07 +- 16.83 (p = 0.0094) and Km front from 40.72 +- 1.60 to 48.87 +- 5.83 (p = 0.0037) in 4D group and in the 8D group average Kmax increased from 42.22 +- 1.54 to 62.95 +- 12.67 (p = 0.0001) and K2 front 40.46 +- 1.64 to 51.51 +- 9.63 (p = 0.0037). There were no significant differences in refractive changes between the 4D and 8D groups after lenticule implantation. CONCLUSION: Intrastromal corneal lenticule implantation induces changes in corneal refractive parameters. In both groups, the implantation induced a significant increase of an anterior corneal steepening without any significant influence on posterior corneal flattening. Corneal lenticule implantation did not lead to any significant change of corneal astigmatism. However, in order to have more precise data for future clinical applications we need to continue with the experiments and verify the results on human corneas.

Název v anglickém jazyce

Refractive Outcome After Corneal Lenticule Implantation Ex Vivo Non-Human Study

Popis výsledku anglicky

PURPOSE: To evaluate changes in corneal refractive parameters after implantation of a stromal lenticule of different thickness. We assume that the refractive outcome depends on the optical power of the used lenticule. METHODS: We conducted an ex-vivo non-human study on 33 normotonic porcine eyeballs divided into two groups, for 4D and 8D human lenticule implantation. Corneal stromal lenticules were obtained as a by-product from a laser procedure ReLEx SMILE. We evaluated corneal refractive parameters measured on Oculus Pentacam(C) device before and immediately after the intrastromal lenticule implantation. RESULTS: There was no statistically significant difference in corneal refractive parameters between the eyeball groups before lenticule implantation. In both groups, the intrastromal implantation in the depth of 300um led to a significant increase of central corneal pachymetry and corneal anterior steepening. In the 4D group the average central corneal pachymetry increased from 903 +- 124.59 to 1230 +- 148.99 (p = 0.0022) and in 8D group from 733.35 +- 69.60 to 1109 +- 161.64 (p = 0.0008). Induced changes in other studied parameters were not statistically significant, Kmax changed from 45.57 +- 2.78 to 72.07 +- 16.83 (p = 0.0094) and Km front from 40.72 +- 1.60 to 48.87 +- 5.83 (p = 0.0037) in 4D group and in the 8D group average Kmax increased from 42.22 +- 1.54 to 62.95 +- 12.67 (p = 0.0001) and K2 front 40.46 +- 1.64 to 51.51 +- 9.63 (p = 0.0037). There were no significant differences in refractive changes between the 4D and 8D groups after lenticule implantation. CONCLUSION: Intrastromal corneal lenticule implantation induces changes in corneal refractive parameters. In both groups, the implantation induced a significant increase of an anterior corneal steepening without any significant influence on posterior corneal flattening. Corneal lenticule implantation did not lead to any significant change of corneal astigmatism. However, in order to have more precise data for future clinical applications we need to continue with the experiments and verify the results on human corneas.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Eye Research

ISSN

0271-3683

e-ISSN

1460-2202

Svazek periodika

48

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

645-650

Kód UT WoS článku

000962638700001

EID výsledku v databázi Scopus

2-s2.0-85151660475