Nature of Neurological Complications and Outcome After Surgery For Type A Aortic Dissection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926827" target="_blank" >RIV/00064173:_____/24:43926827 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43926827

Výsledek na webu

<a href="https://doi.org/10.1016/j.amjcard.2024.03.001" target="_blank" >https://doi.org/10.1016/j.amjcard.2024.03.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amjcard.2024.03.001" target="_blank" >10.1016/j.amjcard.2024.03.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nature of Neurological Complications and Outcome After Surgery For Type A Aortic Dissection

Popis výsledku v původním jazyce

Surgery for type A aortic dissection (TAAD) is frequently complicated by neurological complications. The prognostic impact of neurological complications of different nature has been investigated in this study. The subjects of this analysis were 3902 patients who underwent surgery for acute TAAD from the multicenter European Registry of Type A Aortic Dissection (ERTAAD). During the index hospitalization, 722 (18.5%) patients suffered stroke/global brain ischemia. Ischemic stroke was detected in 539 patients (13.8%), hemorrhagic stroke in 76 patients (1.9%) and global brain ischemia in 177 patients (4.5%), with a few patients having had findings of more than one of these conditions. In-hospital mortality was increased significantly among patients with postoperative ischemic stroke (25.6%, adjusted OR 2.422, 95%CI 1.825-3.216), hemorrhagic stroke (48.7%, adjusted OR 4.641, 95%CI 2.524-8.533) and global brain ischemia (74.0%, adjusted OR 22.275, 95%CI 14.537-35.524) compared to patients without neurological complications (13.5%). Similarly, patients who suffered ischemic stroke (46.3%, adjusted HR 1.719, 95%CI 1.434-2.059), hemorrhagic stroke (62.8%, adjusted HR 3.236, 95%CI 2.314-4.525) and global brain ischemia (83.9%, adjusted HR 12.777, 95%CI 10.325-15.810) had significantly higher 5-year mortality compared to patients without postoperative neurological complications (27.5%). The negative prognostic effect of neurological complications on survival vanished about one year after surgery. In conclusion, postoperative ischemic stroke, hemorrhagic stroke, and global cerebral ischemia increased early and mid-term mortality after surgery for acute TAAD. The magnitude of risk of mortality increased with the severity of the neurological complications, with postoperative hemorrhagic stroke and global brain ischemia being highly lethal complications.

Název v anglickém jazyce

Nature of Neurological Complications and Outcome After Surgery For Type A Aortic Dissection

Popis výsledku anglicky

Surgery for type A aortic dissection (TAAD) is frequently complicated by neurological complications. The prognostic impact of neurological complications of different nature has been investigated in this study. The subjects of this analysis were 3902 patients who underwent surgery for acute TAAD from the multicenter European Registry of Type A Aortic Dissection (ERTAAD). During the index hospitalization, 722 (18.5%) patients suffered stroke/global brain ischemia. Ischemic stroke was detected in 539 patients (13.8%), hemorrhagic stroke in 76 patients (1.9%) and global brain ischemia in 177 patients (4.5%), with a few patients having had findings of more than one of these conditions. In-hospital mortality was increased significantly among patients with postoperative ischemic stroke (25.6%, adjusted OR 2.422, 95%CI 1.825-3.216), hemorrhagic stroke (48.7%, adjusted OR 4.641, 95%CI 2.524-8.533) and global brain ischemia (74.0%, adjusted OR 22.275, 95%CI 14.537-35.524) compared to patients without neurological complications (13.5%). Similarly, patients who suffered ischemic stroke (46.3%, adjusted HR 1.719, 95%CI 1.434-2.059), hemorrhagic stroke (62.8%, adjusted HR 3.236, 95%CI 2.314-4.525) and global brain ischemia (83.9%, adjusted HR 12.777, 95%CI 10.325-15.810) had significantly higher 5-year mortality compared to patients without postoperative neurological complications (27.5%). The negative prognostic effect of neurological complications on survival vanished about one year after surgery. In conclusion, postoperative ischemic stroke, hemorrhagic stroke, and global cerebral ischemia increased early and mid-term mortality after surgery for acute TAAD. The magnitude of risk of mortality increased with the severity of the neurological complications, with postoperative hemorrhagic stroke and global brain ischemia being highly lethal complications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Cardiology

ISSN

0002-9149

e-ISSN

1879-1913

Svazek periodika

219

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

85-91

Kód UT WoS článku

001230577500001

EID výsledku v databázi Scopus

2-s2.0-85190341947