Radiation-Related Fractures after Radical Radiotherapy for Cervical and Endometrial Cancers: Are There Any Differences?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926928" target="_blank" >RIV/00064173:_____/24:43926928 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43926928 RIV/00216208:11130/24:10479549

Výsledek na webu

<a href="https://doi.org/10.3390/diagnostics14080810" target="_blank" >https://doi.org/10.3390/diagnostics14080810</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/diagnostics14080810" target="_blank" >10.3390/diagnostics14080810</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiation-Related Fractures after Radical Radiotherapy for Cervical and Endometrial Cancers: Are There Any Differences?

Popis výsledku v původním jazyce

In this study, we reviewed CT/MRI scans and studied the rates of radiation-related fractures in subjects treated for cervical cancer (CC, 63 subjects) by radical radiotherapy (RT) and in subjects treated for endometrial cancer (EC, 64 subjects) by radical surgery and RT. The differences between bone density measured in L1 on pretreatment CT, age and body mass index (BMI) were evaluated. Despite significant differences in RT total dose, age, BMI, etc., between both groups, the rate of radiation-related fractures was similar: 28.6% of CC versus 26.6% of EC subjects. CC subjects with fractures were significantly older (62.4 +- 10.1 vs. 49.0 +- 12.4 years; p &lt; 0.001), and their bone densities were significantly lower (106.3 +- 40.0 vs. 168.2 +- 49.5 HU; p &lt; 0.001); no difference in BMI was found. EC subjects with fractures were without significant difference in age but had significantly lower bone densities (103.8 +- 29.0 vs. 133.8 +- 42.3 HU; p = 0.009) and BMIs (26.1 +- 4.9 vs. 31.8 +- 6.9 kg/m2; p = 0.003). Bone density strongly correlated with age (r = MINUS SIGN 0.755) only in CC subjects. Subjects with fractures from both groups had similarly low bone densities (106.3 +- 40.0 vs. 103.8 +- 29.0 HU; p = 0.829); however, no correlation between bone density and BMI was found. The rate of radiation-related fractures in both groups was clearly associated only with low pretreatment bone density, reflecting osteoporosis

Název v anglickém jazyce

Radiation-Related Fractures after Radical Radiotherapy for Cervical and Endometrial Cancers: Are There Any Differences?

Popis výsledku anglicky

In this study, we reviewed CT/MRI scans and studied the rates of radiation-related fractures in subjects treated for cervical cancer (CC, 63 subjects) by radical radiotherapy (RT) and in subjects treated for endometrial cancer (EC, 64 subjects) by radical surgery and RT. The differences between bone density measured in L1 on pretreatment CT, age and body mass index (BMI) were evaluated. Despite significant differences in RT total dose, age, BMI, etc., between both groups, the rate of radiation-related fractures was similar: 28.6% of CC versus 26.6% of EC subjects. CC subjects with fractures were significantly older (62.4 +- 10.1 vs. 49.0 +- 12.4 years; p &lt; 0.001), and their bone densities were significantly lower (106.3 +- 40.0 vs. 168.2 +- 49.5 HU; p &lt; 0.001); no difference in BMI was found. EC subjects with fractures were without significant difference in age but had significantly lower bone densities (103.8 +- 29.0 vs. 133.8 +- 42.3 HU; p = 0.009) and BMIs (26.1 +- 4.9 vs. 31.8 +- 6.9 kg/m2; p = 0.003). Bone density strongly correlated with age (r = MINUS SIGN 0.755) only in CC subjects. Subjects with fractures from both groups had similarly low bone densities (106.3 +- 40.0 vs. 103.8 +- 29.0 HU; p = 0.829); however, no correlation between bone density and BMI was found. The rate of radiation-related fractures in both groups was clearly associated only with low pretreatment bone density, reflecting osteoporosis

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diagnostics

ISSN

2075-4418

e-ISSN

2075-4418

Svazek periodika

14

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

810

Kód UT WoS článku

001211441700001

EID výsledku v databázi Scopus

2-s2.0-85191406031