Liver fat response to two days fasting and two days isocaloric high-carbohydrate refeeding in lean and obese women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43927669" target="_blank" >RIV/00064173:_____/24:43927669 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43927669 RIV/00023001:_____/24:00085224

Výsledek na webu

<a href="https://doi.org/10.1016/j.numecd.2024.09.030" target="_blank" >https://doi.org/10.1016/j.numecd.2024.09.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.numecd.2024.09.030" target="_blank" >10.1016/j.numecd.2024.09.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Liver fat response to two days fasting and two days isocaloric high-carbohydrate refeeding in lean and obese women

Popis výsledku v původním jazyce

BACKGROUND AND AIMS: Prolonged fasting, which leads to the mobilization of fat from adipose tissue, can result in the development of hepatosteatosis. However, it is not yet known whether the accumulation of fat in the liver after fasting can be affected by concurrent obesity. Therefore, this study aimed to assess how excessive adiposity influences changes in liver fat content induced by fasting and subsequent refeeding. METHODS AND RESULTS: Ten lean women and eleven women with obesity (age: 36.4 +- 7.9 and 34.5 +- 7.9 years, BMI: 21.4 +- 1.7 and 34.5 +- 4.8 kg/m(2)) underwent a 60-h fasting period followed by 2 days of isocaloric high-carbohydrate refeeding. Magnetic resonance spectroscopy (MRS) examinations of liver were conducted at baseline, after 48 h of fasting, and at the end of refeeding period. Hepatic fat content (HFC) increased in lean women after fasting, whereas no statistically significant change in HFC was observed in women with obesity. Additionally, fasting led to significant reductions in liver volume in both groups, likely attributable to glycogen depletion, with subsequent restoration upon refeeding. Notably, changes in hepatic fat volume (HFV) rather than HFC inversely correlated with baseline liver fat content and HOMA-IR. CONCLUSION: We demonstrated that prolonged fasting results in accumulation of fat in the liver in lean subjects only and that this accumulation is inversely related to baseline fat content and insulin resistance. Moreover, the study underscored the importance of evaluating hepatic fat volume rather than hepatic fat content in studies that involve considerable changes in hepatic lean volume.

Název v anglickém jazyce

Liver fat response to two days fasting and two days isocaloric high-carbohydrate refeeding in lean and obese women

Popis výsledku anglicky

BACKGROUND AND AIMS: Prolonged fasting, which leads to the mobilization of fat from adipose tissue, can result in the development of hepatosteatosis. However, it is not yet known whether the accumulation of fat in the liver after fasting can be affected by concurrent obesity. Therefore, this study aimed to assess how excessive adiposity influences changes in liver fat content induced by fasting and subsequent refeeding. METHODS AND RESULTS: Ten lean women and eleven women with obesity (age: 36.4 +- 7.9 and 34.5 +- 7.9 years, BMI: 21.4 +- 1.7 and 34.5 +- 4.8 kg/m(2)) underwent a 60-h fasting period followed by 2 days of isocaloric high-carbohydrate refeeding. Magnetic resonance spectroscopy (MRS) examinations of liver were conducted at baseline, after 48 h of fasting, and at the end of refeeding period. Hepatic fat content (HFC) increased in lean women after fasting, whereas no statistically significant change in HFC was observed in women with obesity. Additionally, fasting led to significant reductions in liver volume in both groups, likely attributable to glycogen depletion, with subsequent restoration upon refeeding. Notably, changes in hepatic fat volume (HFV) rather than HFC inversely correlated with baseline liver fat content and HOMA-IR. CONCLUSION: We demonstrated that prolonged fasting results in accumulation of fat in the liver in lean subjects only and that this accumulation is inversely related to baseline fat content and insulin resistance. Moreover, the study underscored the importance of evaluating hepatic fat volume rather than hepatic fat content in studies that involve considerable changes in hepatic lean volume.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition, Metabolism and Cardiovascular Diseases

ISSN

0939-4753

e-ISSN

1590-3729

Svazek periodika

34

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

2690-2695

Kód UT WoS článku

001358764800001

EID výsledku v databázi Scopus

2-s2.0-85206891048