Evaluating early mobilisation in critically ill COVID-19 patients: secondary analysis from the ESICM UNITE-COVID-II multicentre observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928440" target="_blank" >RIV/00064173:_____/25:43928440 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/25:43928440

Výsledek na webu

<a href="https://doi.org/10.1016/j.accpm.2025.101550" target="_blank" >https://doi.org/10.1016/j.accpm.2025.101550</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.accpm.2025.101550" target="_blank" >10.1016/j.accpm.2025.101550</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluating early mobilisation in critically ill COVID-19 patients: secondary analysis from the ESICM UNITE-COVID-II multicentre observational study

Popis výsledku v původním jazyce

BACKGROUND: Early mobilisation (EM) within the first 72 hours of ICU admission is essential for preventing ICU-acquired weakness; however, mobilisation rates remained low among mechanically ventilated (MV) COVID-19 patients during the pandemic waves. This study aimed to characterise the association between EM and 60-day outcomes. METHODS: A multicentre observational study conducted by the European Society of Intensive Care Medicine (ESICM) examined mobilisation strategies during the second COVID-19 wave (UNITE-COVIDed2021). All patients with confirmed SARS-CoV-2 infection who were in the ICU on the peak day between 1 January and 1 June 2021 were included. The analysis expanded on the UNITE-COVIDed2020 study, comparing the first and second COVID-19 waves using a combined dataset. RESULTS: Data from 2,053 patients during the second wave across 103 ICUs in 35 countries were analysed and compared with 4,190 patients from the first wave. EM was achieved in 801 (39%) vs. 1114 (27%), p &lt; 0.001, respectively. In the combined cohort, MV on admission significantly reduced the likelihood of EM (OR 0.29, 95% CI: 0.25-0.33, p = 0.001). While EM did not improve ICU or hospital length of stay, it was associated with reduced 60-day mortality (OR 0.74, 95% CI: 0.64-0.86, p = 0.001) and transfer rates to other care facilities (OR 0.74, 95% CI: 0.59-0.94, p = 0.001). CONCLUSION: EM is feasible and beneficial for critically ill COVID-19 patients. It was associated with reduced mortality and lower transfer rates to other care facilities, which underscores the critical role of EM in enhancing patient recovery during a pandemic.

Název v anglickém jazyce

Evaluating early mobilisation in critically ill COVID-19 patients: secondary analysis from the ESICM UNITE-COVID-II multicentre observational study

Popis výsledku anglicky

BACKGROUND: Early mobilisation (EM) within the first 72 hours of ICU admission is essential for preventing ICU-acquired weakness; however, mobilisation rates remained low among mechanically ventilated (MV) COVID-19 patients during the pandemic waves. This study aimed to characterise the association between EM and 60-day outcomes. METHODS: A multicentre observational study conducted by the European Society of Intensive Care Medicine (ESICM) examined mobilisation strategies during the second COVID-19 wave (UNITE-COVIDed2021). All patients with confirmed SARS-CoV-2 infection who were in the ICU on the peak day between 1 January and 1 June 2021 were included. The analysis expanded on the UNITE-COVIDed2020 study, comparing the first and second COVID-19 waves using a combined dataset. RESULTS: Data from 2,053 patients during the second wave across 103 ICUs in 35 countries were analysed and compared with 4,190 patients from the first wave. EM was achieved in 801 (39%) vs. 1114 (27%), p &lt; 0.001, respectively. In the combined cohort, MV on admission significantly reduced the likelihood of EM (OR 0.29, 95% CI: 0.25-0.33, p = 0.001). While EM did not improve ICU or hospital length of stay, it was associated with reduced 60-day mortality (OR 0.74, 95% CI: 0.64-0.86, p = 0.001) and transfer rates to other care facilities (OR 0.74, 95% CI: 0.59-0.94, p = 0.001). CONCLUSION: EM is feasible and beneficial for critically ill COVID-19 patients. It was associated with reduced mortality and lower transfer rates to other care facilities, which underscores the critical role of EM in enhancing patient recovery during a pandemic.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30221 - Critical care medicine and Emergency medicine

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anaesthesia, Critical Care &amp; Pain Medicine

ISSN

2352-5568

e-ISSN

2352-5568

Svazek periodika

44

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

9

Strana od-do

101550

Kód UT WoS článku

001511985400001

EID výsledku v databázi Scopus

2-s2.0-105008022781