Clinical Pharmaceutical Care in Nursing Home Residents as a Cornerstone for Drug-Related Problems Identification

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928441" target="_blank" >RIV/00064173:_____/25:43928441 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10498132 RIV/00216208:11120/25:43928441 RIV/00216208:11130/25:10498132 RIV/27283933:_____/25:N0000034 a 2 dalších

Výsledek na webu

<a href="https://doi.org/10.1111/cts.70222" target="_blank" >https://doi.org/10.1111/cts.70222</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cts.70222" target="_blank" >10.1111/cts.70222</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical Pharmaceutical Care in Nursing Home Residents as a Cornerstone for Drug-Related Problems Identification

Popis výsledku v původním jazyce

Rational prescribing in geriatrics represents an important ethical as well as socio-economic issue. The aim of this project was to analyze the drug-related problems (DRPs) among the Czech nursing home residents and increase public awareness of further possible employment of clinical pharmacists in social care. The project was designed as a multicenter observational study. A total of 16 nursing homes and 800 participants with an average age of 84.6 +- 7.3 years were included in the study. Of them, a DRP was noted in 93.3% of people. The total amount of DRPs identified was 2215, which means an average of 2.8 +- 1.6 DRPs per patient. The most common DRPs identified were &apos;overtreatment&apos; (19.5%), &apos;undertreatment&apos; (12.8%), inappropriate dose (10.6%), recommendations for laboratory monitoring (10.4%) and adverse effects (10.3%). Of different drug classes, BZDs (OR 16.6, 95% CI 1.0-270.2), PPIs (OR 2.5, 95% CI 1.1-5.6) and NSAIDs (OR 4.4, 95% CI 1.1-18.3) were identified to be most commonly associated with DRPs. The risk of DRP identification clearly increased with the number of drugs used, with seven drugs demonstrated as the best cut-off for predicting DRP identification (AUC 0.842, sensitivity 0.602; specificity 0.796). &apos;SENIOR&apos; project has confirmed a high rate of excessive polypharmacy among nursing home residents in the Czech republic resulting in high risk of potential and manifested DRPs. The project emphasized the role of clinical pharmacists in optimizing safety and effectiveness of treatment among older nursing home residents.

Název v anglickém jazyce

Clinical Pharmaceutical Care in Nursing Home Residents as a Cornerstone for Drug-Related Problems Identification

Popis výsledku anglicky

Rational prescribing in geriatrics represents an important ethical as well as socio-economic issue. The aim of this project was to analyze the drug-related problems (DRPs) among the Czech nursing home residents and increase public awareness of further possible employment of clinical pharmacists in social care. The project was designed as a multicenter observational study. A total of 16 nursing homes and 800 participants with an average age of 84.6 +- 7.3 years were included in the study. Of them, a DRP was noted in 93.3% of people. The total amount of DRPs identified was 2215, which means an average of 2.8 +- 1.6 DRPs per patient. The most common DRPs identified were &apos;overtreatment&apos; (19.5%), &apos;undertreatment&apos; (12.8%), inappropriate dose (10.6%), recommendations for laboratory monitoring (10.4%) and adverse effects (10.3%). Of different drug classes, BZDs (OR 16.6, 95% CI 1.0-270.2), PPIs (OR 2.5, 95% CI 1.1-5.6) and NSAIDs (OR 4.4, 95% CI 1.1-18.3) were identified to be most commonly associated with DRPs. The risk of DRP identification clearly increased with the number of drugs used, with seven drugs demonstrated as the best cut-off for predicting DRP identification (AUC 0.842, sensitivity 0.602; specificity 0.796). &apos;SENIOR&apos; project has confirmed a high rate of excessive polypharmacy among nursing home residents in the Czech republic resulting in high risk of potential and manifested DRPs. The project emphasized the role of clinical pharmacists in optimizing safety and effectiveness of treatment among older nursing home residents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/EH22_008%2F0004607" target="_blank" >EH22_008/0004607: Nové technologie pro translační výzkum ve farmaceutických vědách /NETPHARM</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and Translational Science

ISSN

1752-8054

e-ISSN

1752-8062

Svazek periodika

18

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

"e70222"

Kód UT WoS článku

001490943700001

EID výsledku v databázi Scopus

2-s2.0-105005578064