Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928647" target="_blank" >RIV/00064173:_____/25:43928647 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/25:43928647

Výsledek na webu

<a href="https://doi.org/10.1080/1354750X.2025.2536009" target="_blank" >https://doi.org/10.1080/1354750X.2025.2536009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1354750X.2025.2536009" target="_blank" >10.1080/1354750X.2025.2536009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy

Popis výsledku v původním jazyce

INTRODUCTION: The mechanism of cell death during pulsed-field (PFA) ablation seems substantially different from mechanisms using thermal energy sources (e.g., radiofrequency energy, RFA). In human in vivo studies, apoptosis is often described as the leading cause of PFA-induced cell death. This study aimed to specify the cause by comparing markers of cardiac necrosis and apoptosis during ablation using PFA and RFA energy. METHODS AND RESULTS: Patients with AF indicated for pulmonary vein isolation (PVI) were enrolled and randomly assigned to undergo PVI using RFA (CARTO Smart Touch, Biosense Webster) or PFA (Farapulse, Boston-Scientific) energy. Markers of myocardial necrosis (troponin I) and apoptosis (soluble cleaved caspase-3, Fas ligand) were measured before and one day after the procedure. RESULTS: Sixty-five patients were enrolled in the PFA (n = 33) and RFA (n = 32) groups. Both groups had similar baseline characteristics (age 60.5 +- 12.7 vs. 64.0 +- 10.7; paroxysmal AF 60.6% vs. 62.5% of patients). The maximum troponin concentration on 1d + was substantially higher in the PFA group (median and interquartile rages) 10,102 ng/L; 8,272-14,207 vs. 1,006 ng/L; 603-1,433). No increase in Fas or caspase-3 was present after PFA, and no differences in the concentration of these apoptotic markers were present between PFA and RFA patients 1d after the procedure. CONCLUSION: In the acute clinical in vivo setting, apoptosis does not seem to be the leading cause of cardiomyocyte death after pulsed-field ablation for AF.

Název v anglickém jazyce

Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy

Popis výsledku anglicky

INTRODUCTION: The mechanism of cell death during pulsed-field (PFA) ablation seems substantially different from mechanisms using thermal energy sources (e.g., radiofrequency energy, RFA). In human in vivo studies, apoptosis is often described as the leading cause of PFA-induced cell death. This study aimed to specify the cause by comparing markers of cardiac necrosis and apoptosis during ablation using PFA and RFA energy. METHODS AND RESULTS: Patients with AF indicated for pulmonary vein isolation (PVI) were enrolled and randomly assigned to undergo PVI using RFA (CARTO Smart Touch, Biosense Webster) or PFA (Farapulse, Boston-Scientific) energy. Markers of myocardial necrosis (troponin I) and apoptosis (soluble cleaved caspase-3, Fas ligand) were measured before and one day after the procedure. RESULTS: Sixty-five patients were enrolled in the PFA (n = 33) and RFA (n = 32) groups. Both groups had similar baseline characteristics (age 60.5 +- 12.7 vs. 64.0 +- 10.7; paroxysmal AF 60.6% vs. 62.5% of patients). The maximum troponin concentration on 1d + was substantially higher in the PFA group (median and interquartile rages) 10,102 ng/L; 8,272-14,207 vs. 1,006 ng/L; 603-1,433). No increase in Fas or caspase-3 was present after PFA, and no differences in the concentration of these apoptotic markers were present between PFA and RFA patients 1d after the procedure. CONCLUSION: In the acute clinical in vivo setting, apoptosis does not seem to be the leading cause of cardiomyocyte death after pulsed-field ablation for AF.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NU21-02-00388" target="_blank" >NU21-02-00388: Katetrizační ablace vs. modifikace rizikových faktorů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomarkers

ISSN

1354-750X

e-ISSN

1366-5804

Svazek periodika

30

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

327-331

Kód UT WoS článku

001541428400001

EID výsledku v databázi Scopus

2-s2.0-105012426500