Radiation burden from recurrent computed tomography examinations in patients treated with immunotherapy for malignant melanoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928699" target="_blank" >RIV/00064173:_____/25:43928699 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/25:43928699 RIV/00216208:11130/25:10500313 RIV/00023001:_____/25:00085805

Výsledek na webu

<a href="https://doi.org/10.21037/qims-24-2102" target="_blank" >https://doi.org/10.21037/qims-24-2102</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21037/qims-24-2102" target="_blank" >10.21037/qims-24-2102</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiation burden from recurrent computed tomography examinations in patients treated with immunotherapy for malignant melanoma

Popis výsledku v původním jazyce

BACKGROUND: Computed tomography (CT) examination is among the imaging modalities burdened with a relatively high dose of ionizing radiation. Nowadays, CT is an integral part of modern medicine. In the field of oncology care, patients undergo repeated CT examinations for initial diagnosis, staging, and follow-up. However, we usually only have a rough idea of how high the radiation exposure these examinations actually represent for the patient. It is general agreement that received effective dose (ED) greater than 100 mSv represents a significantly higher risk of radiation-induced fatal malignancy over the course of the patient&apos;s life. In our study, we focused on the radiation burden that these recurrent CT scans represent for patients undergoing immunotherapy for metastatic malignant melanoma. METHODS: Our study had a retrospective design. Study group consisted of all patients treated with immunotherapy for metastatic malignant melanoma between 2016 and 2021. We included 54 patients with median age of 66 years, interquartile range (IQR) 15 years. We retrospectively calculated the EDs of their individual CT examinations (n=622) then calculated the cumulative dose (CED) for each patient. RESULTS: Study subjects underwent median 8 CT examinations (IQR, 9 examinations), with a minimum 2 and a maximum 25 CT examinations. In 35 patients (64%) CED exceeded 100 mSv, in 17 (31%) subjects CED was over 200 mSv and in 11 (20%) was over 300 mSv. The highest achieved CED was 547.7 mSv. CONCLUSIONS: We proved that recurrent CT scans performed for follow-up care are associated with a high CED. A CED higher than 100 mSv, is considered as significant for the risk of developing radiation-induced malignancy later in the patient&apos;s life. Although other factors such as age, gender or individual sensitivity must be taken into account, the high CED from such examinations should be considered, especially when creating follow-up care plans and recommendations.

Název v anglickém jazyce

Radiation burden from recurrent computed tomography examinations in patients treated with immunotherapy for malignant melanoma

Popis výsledku anglicky

BACKGROUND: Computed tomography (CT) examination is among the imaging modalities burdened with a relatively high dose of ionizing radiation. Nowadays, CT is an integral part of modern medicine. In the field of oncology care, patients undergo repeated CT examinations for initial diagnosis, staging, and follow-up. However, we usually only have a rough idea of how high the radiation exposure these examinations actually represent for the patient. It is general agreement that received effective dose (ED) greater than 100 mSv represents a significantly higher risk of radiation-induced fatal malignancy over the course of the patient&apos;s life. In our study, we focused on the radiation burden that these recurrent CT scans represent for patients undergoing immunotherapy for metastatic malignant melanoma. METHODS: Our study had a retrospective design. Study group consisted of all patients treated with immunotherapy for metastatic malignant melanoma between 2016 and 2021. We included 54 patients with median age of 66 years, interquartile range (IQR) 15 years. We retrospectively calculated the EDs of their individual CT examinations (n=622) then calculated the cumulative dose (CED) for each patient. RESULTS: Study subjects underwent median 8 CT examinations (IQR, 9 examinations), with a minimum 2 and a maximum 25 CT examinations. In 35 patients (64%) CED exceeded 100 mSv, in 17 (31%) subjects CED was over 200 mSv and in 11 (20%) was over 300 mSv. The highest achieved CED was 547.7 mSv. CONCLUSIONS: We proved that recurrent CT scans performed for follow-up care are associated with a high CED. A CED higher than 100 mSv, is considered as significant for the risk of developing radiation-induced malignancy later in the patient&apos;s life. Although other factors such as age, gender or individual sensitivity must be taken into account, the high CED from such examinations should be considered, especially when creating follow-up care plans and recommendations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Quantitative Imaging in Medicine and Surgery

ISSN

2223-4292

e-ISSN

2223-4306

Svazek periodika

15

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

10

Strana od-do

6594-6603

Kód UT WoS článku

001551243600001

EID výsledku v databázi Scopus

2-s2.0-105013503566