Microbiological findings and antimicrobial resistance dynamics in pathogens isolated from patients with toxic epidermal necrolysis: a single center experience

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43929307" target="_blank" >RIV/00064173:_____/25:43929307 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143753 RIV/00216208:11120/25:43929307 RIV/65269705:_____/25:00083707

Výsledek na webu

<a href="https://doi.org/10.61568/emi/11-6600/20251001/141813" target="_blank" >https://doi.org/10.61568/emi/11-6600/20251001/141813</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.61568/emi/11-6600/20251001/141813" target="_blank" >10.61568/emi/11-6600/20251001/141813</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microbiological findings and antimicrobial resistance dynamics in pathogens isolated from patients with toxic epidermal necrolysis: a single center experience

Popis výsledku v původním jazyce

Introduction: Toxic epidermal necrolysis (TEN) is one of the most life-threatening skin exfoliative disorders. The disease is frequently misdiagnosed or diagnosed with a long delay. This, together with the unique pathology, leads to a high mortality of affected patients. The high risk of infections associated with extensive loss of skin and impaired function of the immune system is one of the most common complications in TEN patients. Methods: All patients treated at our clinic with a diagnosis of TEN between January 1, 1996, and December 31, 2020, were included in this study. Basic epidemiological parameters, the incidence of infectious complications in individual compartments, clinical laboratory and microbiological parameters, and antimicrobial resistance of pathogens isolated during the hospital stay were collected. Results: In total, 498 potentially pathogenic microorganisms (PPMs) were isolated in our patient group, i.e., on average more than 35 isolated PPMs per patient. Of these, 155 pathogens fell into the gram-positive spectrum (31.1%), and 331 into the gram-negative spectrum (66.5%). The effect of corticosteroid therapy on overall survival is also an interesting indicator. In patients with multifocal infection, the maximum corticosteroid dose was 965 mg of methylprednisolone, while in patients without multifocal infection, the maximum dose was 2.333 mg methylprednisolone (p = 0.032). Last but not least, we mapped the most frequently occurring pathogens, dominated by gram-negative bacteria, in particular Klebsiella sp. and Enterobacter sp. We also described the presence of antibiotic resistance in epidemiologically important pathogens in TEN patients with infectious complications. Conclusion: We successfully identified basic epidemiological parameters in a cohort of patients treated with TEN along with the most frequent representatives of infectious complications. We were able to identify risk factors for the development of infectious complications and their impact on further complications of treatment as well as patient mortality.

Název v anglickém jazyce

Microbiological findings and antimicrobial resistance dynamics in pathogens isolated from patients with toxic epidermal necrolysis: a single center experience

Popis výsledku anglicky

Introduction: Toxic epidermal necrolysis (TEN) is one of the most life-threatening skin exfoliative disorders. The disease is frequently misdiagnosed or diagnosed with a long delay. This, together with the unique pathology, leads to a high mortality of affected patients. The high risk of infections associated with extensive loss of skin and impaired function of the immune system is one of the most common complications in TEN patients. Methods: All patients treated at our clinic with a diagnosis of TEN between January 1, 1996, and December 31, 2020, were included in this study. Basic epidemiological parameters, the incidence of infectious complications in individual compartments, clinical laboratory and microbiological parameters, and antimicrobial resistance of pathogens isolated during the hospital stay were collected. Results: In total, 498 potentially pathogenic microorganisms (PPMs) were isolated in our patient group, i.e., on average more than 35 isolated PPMs per patient. Of these, 155 pathogens fell into the gram-positive spectrum (31.1%), and 331 into the gram-negative spectrum (66.5%). The effect of corticosteroid therapy on overall survival is also an interesting indicator. In patients with multifocal infection, the maximum corticosteroid dose was 965 mg of methylprednisolone, while in patients without multifocal infection, the maximum dose was 2.333 mg methylprednisolone (p = 0.032). Last but not least, we mapped the most frequently occurring pathogens, dominated by gram-negative bacteria, in particular Klebsiella sp. and Enterobacter sp. We also described the presence of antibiotic resistance in epidemiologically important pathogens in TEN patients with infectious complications. Conclusion: We successfully identified basic epidemiological parameters in a cohort of patients treated with TEN along with the most frequent representatives of infectious complications. We were able to identify risk factors for the development of infectious complications and their impact on further complications of treatment as well as patient mortality.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epidemiologie, mikrobiologie, imunologie

ISSN

1210-7913

e-ISSN

1805-451X

Svazek periodika

74

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

205-215

Kód UT WoS článku

001665600600001

EID výsledku v databázi Scopus

2-s2.0-105027597188