Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F14%3A%230000684" target="_blank" >RIV/00064190:_____/14:#0000684 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/14:10283046 RIV/00064190:_____/14:#0000816 RIV/00216208:11110/14:10283046 RIV/00216208:11130/14:10283046

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.critrevonc.2013.10.001" target="_blank" >http://dx.doi.org/10.1016/j.critrevonc.2013.10.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.critrevonc.2013.10.001" target="_blank" >10.1016/j.critrevonc.2013.10.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application

Popis výsledku v původním jazyce

Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men characterized by distinct biologic features and clinical behavior. Both genetic predispositions and environmental factors probably play a substantial role in their etiology. TGTCs arise from a malignant transformation of primordial germ cells in a process that starts prenatally, is often associated with a certain degree of gonadal dysgenesis, and involves the acquirement of several specific aberrations, including activation of SCF-CKIT, amplification of 12p with up-regulation of stem cell genes, and subsequent genetic and epigenetic alterations. Their embryonic and germ origin determines the unique sensitivity of TGCTs to platinum-based chemotherapy. Contrary to thevast majority of other malignancies, no molecular prognostic/predictive factors nor targeted therapy is available for patients with these tumors. This review summarizes the principal molecular characteristics of TGCTs that could represen

Název v anglickém jazyce

Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application

Popis výsledku anglicky

Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men characterized by distinct biologic features and clinical behavior. Both genetic predispositions and environmental factors probably play a substantial role in their etiology. TGTCs arise from a malignant transformation of primordial germ cells in a process that starts prenatally, is often associated with a certain degree of gonadal dysgenesis, and involves the acquirement of several specific aberrations, including activation of SCF-CKIT, amplification of 12p with up-regulation of stem cell genes, and subsequent genetic and epigenetic alterations. Their embryonic and germ origin determines the unique sensitivity of TGCTs to platinum-based chemotherapy. Contrary to thevast majority of other malignancies, no molecular prognostic/predictive factors nor targeted therapy is available for patients with these tumors. This review summarizes the principal molecular characteristics of TGCTs that could represen

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12414" target="_blank" >NT12414: Význam genu WT1 a dalších molekulárně-biologických abnormalit jako potenciálních prognostických a prediktivních faktorů u germinálních nádorů varlat</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Critical reviews in oncology/hematology

ISSN

1040-8428

e-ISSN

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Svazek periodika

89

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

19

Strana od-do

366-385

Kód UT WoS článku

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EID výsledku v databázi Scopus

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