Impact of Anti?Tumor Necrosis Factor Alpha Antibodies Administered to Pregnant Women With Inflammatory Bowel Disease on Long-term Outcome of Exposed Children
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F14%3A%230000750" target="_blank" >RIV/00064190:_____/14:#0000750 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/14:10271962 RIV/00216208:11130/14:10271962 RIV/00216208:11140/14:10271962 RIV/00669806:_____/14:10271962 a 4 dalších
Výsledek na webu
<a href="http://dx.doi.org/10.1097/01.MIB.0000440984.86659.4f" target="_blank" >http://dx.doi.org/10.1097/01.MIB.0000440984.86659.4f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/01.MIB.0000440984.86659.4f" target="_blank" >10.1097/01.MIB.0000440984.86659.4f</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Impact of Anti?Tumor Necrosis Factor Alpha Antibodies Administered to Pregnant Women With Inflammatory Bowel Disease on Long-term Outcome of Exposed Children
Popis výsledku v původním jazyce
Background:Prenatal exposure to anti?tumor necrosis factor alpha (TNF-alpha) antibodies seems to be safe for fetal development. Data on long-term outcome of exposed children are missing. Our aim was to assess long-term postnatal development of children exposed to anti?TNF-alpha during pregnancy. Methods:Consecutive children aged equal to or more than 12 months exposed to anti-TNFs prenatally for maternal inflammatory bowel disease in 3 centers in the Czech Republic were enrolled. Data on psychomotor development, infections, antibiotics, vaccination, and allergy were retrospectively obtained from mothers, treating pediatricians, and children's vaccination cards. Furthermore, standardized laboratory tests on humoral and cellular immunity were performed.Results:Twenty-five children exposed to biologicals were included (median age, 34 mo; range, 14?70 mo). All children had normal growth, and all but 1 had normal psychomotor development. Majority (80%) experienced at least 1 infection (mai
Název v anglickém jazyce
Impact of Anti?Tumor Necrosis Factor Alpha Antibodies Administered to Pregnant Women With Inflammatory Bowel Disease on Long-term Outcome of Exposed Children
Popis výsledku anglicky
Background:Prenatal exposure to anti?tumor necrosis factor alpha (TNF-alpha) antibodies seems to be safe for fetal development. Data on long-term outcome of exposed children are missing. Our aim was to assess long-term postnatal development of children exposed to anti?TNF-alpha during pregnancy. Methods:Consecutive children aged equal to or more than 12 months exposed to anti-TNFs prenatally for maternal inflammatory bowel disease in 3 centers in the Czech Republic were enrolled. Data on psychomotor development, infections, antibiotics, vaccination, and allergy were retrospectively obtained from mothers, treating pediatricians, and children's vaccination cards. Furthermore, standardized laboratory tests on humoral and cellular immunity were performed.Results:Twenty-five children exposed to biologicals were included (median age, 34 mo; range, 14?70 mo). All children had normal growth, and all but 1 had normal psychomotor development. Majority (80%) experienced at least 1 infection (mai
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT14300" target="_blank" >NT14300: Etiologie, patogeneze a klinický průběh kožních a imunopatologických nežádoucích účinků biologické léčby idiopatických střevních zánětů</a><br>
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Inflammatory bowel diseases
ISSN
1078-0998
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
495-501
Kód UT WoS článku
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EID výsledku v databázi Scopus
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