Suppressive effect of citalopram on plasma concentrations of thromboxane B-2

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001076" target="_blank" >RIV/00064190:_____/15:#0001076 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/15:10297941

Výsledek na webu

<a href="http://dx.doi.org/10.3109/00365513.2015.1066848" target="_blank" >http://dx.doi.org/10.3109/00365513.2015.1066848</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/00365513.2015.1066848" target="_blank" >10.3109/00365513.2015.1066848</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Suppressive effect of citalopram on plasma concentrations of thromboxane B-2

Popis výsledku v původním jazyce

Background. Citalopram, a selective serotonin reuptake inhibitor (SSRi), is widely used to treat major depression. Patients treated with SSRIs suffer more frequently from bleeding disorders caused by the antiplatelet effect of SSRIs. Methods. To investigate the potential suppressive effect of citalopram treatment on plasma thromboxane B-2 levels and its possible correlation with actual plasma concentration of citalopram. Plasma concentrations of thromboxane B-2 and citalopram were examined in a cohort of 77 aspirin-treated geriatric patients before and in the third week of citalopram therapy. Results. Citalopram therapy led to a signifi cant decrease of plasma concentrations of thromboxane B-2 compared to its levels before initiation of the therapy. Furthermore, we have shown negative correlation in thromboxane B-2 levels and actual plasma concentration of citalopram. Actual plasma concentrations of citalopram were signifi cantly higher compared to younger adult patients treated with similar dose. Conclusions. In this study we have shown that even short-term citalopram therapy led to a suppression of thromboxane B-2 production in aspirin-treated patients. This suppressive effect correlates with actual plasma concentration of citalopram.

Název v anglickém jazyce

Suppressive effect of citalopram on plasma concentrations of thromboxane B-2

Popis výsledku anglicky

Background. Citalopram, a selective serotonin reuptake inhibitor (SSRi), is widely used to treat major depression. Patients treated with SSRIs suffer more frequently from bleeding disorders caused by the antiplatelet effect of SSRIs. Methods. To investigate the potential suppressive effect of citalopram treatment on plasma thromboxane B-2 levels and its possible correlation with actual plasma concentration of citalopram. Plasma concentrations of thromboxane B-2 and citalopram were examined in a cohort of 77 aspirin-treated geriatric patients before and in the third week of citalopram therapy. Results. Citalopram therapy led to a signifi cant decrease of plasma concentrations of thromboxane B-2 compared to its levels before initiation of the therapy. Furthermore, we have shown negative correlation in thromboxane B-2 levels and actual plasma concentration of citalopram. Actual plasma concentrations of citalopram were signifi cantly higher compared to younger adult patients treated with similar dose. Conclusions. In this study we have shown that even short-term citalopram therapy led to a suppression of thromboxane B-2 production in aspirin-treated patients. This suppressive effect correlates with actual plasma concentration of citalopram.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

ISSN

0036-5513

e-ISSN

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Svazek periodika

75

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

615-620

Kód UT WoS článku

000361321700012

EID výsledku v databázi Scopus

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