Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001080" target="_blank" >RIV/00064190:_____/15:#0001080 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/15:00451835 RIV/00216208:11110/15:10294654
Výsledek na webu
<a href="http://clincancerres.aacrjournals.org/content/18/14/3982.long" target="_blank" >http://clincancerres.aacrjournals.org/content/18/14/3982.long</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/carcin/bgu224" target="_blank" >10.1093/carcin/bgu224</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients
Popis výsledku v původním jazyce
This study investigates whether variants in miRNA genes, previously associated with prognosis, can predict CRC clinical outcome in CRC patients from the Czech Republic. Two polymorphisms in miRNAs resulted significantly associated with survival/recurrence in patients undergoing 5-FU-based chemotherapy.Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes that have been previously reported as important in prognosis in patients with stage III CRC and treated with 5-FU-based chemotherapy. Two SNPs (rs4919510 in miR-608 and rs213210 in miR-219-1) were genotyped in 1083 CRC patients recruited in the Czech Republic to evaluate their effect on clinical outcomes. Carriers of the variant T allele in rs213210 and receiving 5-FU chemotherapy were associa
Název v anglickém jazyce
Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients
Popis výsledku anglicky
This study investigates whether variants in miRNA genes, previously associated with prognosis, can predict CRC clinical outcome in CRC patients from the Czech Republic. Two polymorphisms in miRNAs resulted significantly associated with survival/recurrence in patients undergoing 5-FU-based chemotherapy.Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes that have been previously reported as important in prognosis in patients with stage III CRC and treated with 5-FU-based chemotherapy. Two SNPs (rs4919510 in miR-608 and rs213210 in miR-219-1) were genotyped in 1083 CRC patients recruited in the Czech Republic to evaluate their effect on clinical outcomes. Carriers of the variant T allele in rs213210 and receiving 5-FU chemotherapy were associa
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
CARCINOGENESIS
ISSN
0143-3334
e-ISSN
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Svazek periodika
36
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
5
Strana od-do
82-86
Kód UT WoS článku
000347844700011
EID výsledku v databázi Scopus
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