The association between uncarboxylated matrix Gla protein and lipoprotein-associated phospholipase A(2)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001081" target="_blank" >RIV/00064190:_____/15:#0001081 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00061248 RIV/00216208:11110/15:10282629 RIV/00216208:11140/15:10282629 RIV/00669806:_____/15:10282629

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.maturitas.2014.10.003" target="_blank" >http://dx.doi.org/10.1016/j.maturitas.2014.10.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.maturitas.2014.10.003" target="_blank" >10.1016/j.maturitas.2014.10.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The association between uncarboxylated matrix Gla protein and lipoprotein-associated phospholipase A(2)

Popis výsledku v původním jazyce

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is independently associated with cardiovascular risk, probably via inflammatory activity in sclerotic plaque. We speculated whether Lp-PLA(2) has a role in the aetiology of vascular calcifications, estimated from circulating uncarboxylated matrix Gla protein (MGP) species and whether we could find a potential interaction of Lp-PLA(2) and MGP in terms of mortality. Materials and Methods: We examined 798 patients (mean age 65.1 years) with stable vascular disease and followed them in a prospective study. Both, desphospho-uncarboxylated and total MGP (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays, developed by VitaK (Maastricht, The Netherland) Results: Lp-PLA(2) activity was independently positively associated with desphospho-uncarboxylated MGP (dp-ucMGP) [beta coeff = 0.098, p = 0.006]. 1SD of Lp-PLA(2) activity was associated with 37% increased risk (p = 0.001) of elevated dp-ucMGP (>= 977 pmol/L, top quartile). In the Cox proportional hazard model adjusted for conventional risk factors, the patients in the highest quartile of dp-ucMGP or lowest quintile of total-uncarboxylated ucMGP (<2660 nmol/L) had higher risk of all-cause mortality [HRR 2.79 (95% CI 1.97-3.94) and HRR 1.69 (95% CI 1.18-2.42), respectively]. We observed no effect of high Lp-PLA(2) activity (>= 195 nmol/min/mL) on total mortality. Conclusions: We assume that Lp-PLA(2) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA(2) itself.

Název v anglickém jazyce

The association between uncarboxylated matrix Gla protein and lipoprotein-associated phospholipase A(2)

Popis výsledku anglicky

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is independently associated with cardiovascular risk, probably via inflammatory activity in sclerotic plaque. We speculated whether Lp-PLA(2) has a role in the aetiology of vascular calcifications, estimated from circulating uncarboxylated matrix Gla protein (MGP) species and whether we could find a potential interaction of Lp-PLA(2) and MGP in terms of mortality. Materials and Methods: We examined 798 patients (mean age 65.1 years) with stable vascular disease and followed them in a prospective study. Both, desphospho-uncarboxylated and total MGP (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays, developed by VitaK (Maastricht, The Netherland) Results: Lp-PLA(2) activity was independently positively associated with desphospho-uncarboxylated MGP (dp-ucMGP) [beta coeff = 0.098, p = 0.006]. 1SD of Lp-PLA(2) activity was associated with 37% increased risk (p = 0.001) of elevated dp-ucMGP (>= 977 pmol/L, top quartile). In the Cox proportional hazard model adjusted for conventional risk factors, the patients in the highest quartile of dp-ucMGP or lowest quintile of total-uncarboxylated ucMGP (<2660 nmol/L) had higher risk of all-cause mortality [HRR 2.79 (95% CI 1.97-3.94) and HRR 1.69 (95% CI 1.18-2.42), respectively]. We observed no effect of high Lp-PLA(2) activity (>= 195 nmol/min/mL) on total mortality. Conclusions: We assume that Lp-PLA(2) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA(2) itself.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MATURITAS

ISSN

0378-5122

e-ISSN

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Svazek periodika

80

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

7

Strana od-do

82-88

Kód UT WoS článku

000348013900013

EID výsledku v databázi Scopus

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