Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001082" target="_blank" >RIV/00064190:_____/15:#0001082 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/15:00059220

Výsledek na webu

<a href="http://dx.doi.org/10.1111/crj.12102" target="_blank" >http://dx.doi.org/10.1111/crj.12102</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/crj.12102" target="_blank" >10.1111/crj.12102</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis

Popis výsledku v původním jazyce

IntroductionImmune response probably changes during human life, being influenced by cumulative exposure to environmental factors and individual genetic background. MethodsPatients investigated for suspected interstitial lung disease were prospectively enrolled. After completing the diagnostic process, 121 patients were diagnosed extrinsic allergic alveolitis (EAA) and 136 sarcoidosis. Three groups according to age were established (<30 years, 30-60 years, >60 years), clinical manifestation, vital capacity (VC), forced expired volume in 1s (FEV1), lung diffusing capacity for carbon monoxide-transfer factor (TLCO) and bronchoalveolar lavage fluid (BALF) differential cell count were compared among the groups. ResultsAge subgroups of EAA patients did not significantly differ in lung functions. In the group above 60 years, non-significantly higher neutrophils and eosinophils counts and CD4/CD8 ratio were observed. Sarcoidosis patients were significantly younger than EAA group and had significantly better lung functions (VC, FEV1, TLCO). Patients with sarcoidosis above 60 years of age had significantly higher percentages of neutrophils in BALF compared with younger patients. BALF percentage of neutrophils positively correlated with age. ConclusionsPresented results may support the hypothesis that reactivity of immune system changes during the life, which may result in different manifestation of interstitial lung diseases according to age.

Název v anglickém jazyce

Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis

Popis výsledku anglicky

IntroductionImmune response probably changes during human life, being influenced by cumulative exposure to environmental factors and individual genetic background. MethodsPatients investigated for suspected interstitial lung disease were prospectively enrolled. After completing the diagnostic process, 121 patients were diagnosed extrinsic allergic alveolitis (EAA) and 136 sarcoidosis. Three groups according to age were established (<30 years, 30-60 years, >60 years), clinical manifestation, vital capacity (VC), forced expired volume in 1s (FEV1), lung diffusing capacity for carbon monoxide-transfer factor (TLCO) and bronchoalveolar lavage fluid (BALF) differential cell count were compared among the groups. ResultsAge subgroups of EAA patients did not significantly differ in lung functions. In the group above 60 years, non-significantly higher neutrophils and eosinophils counts and CD4/CD8 ratio were observed. Sarcoidosis patients were significantly younger than EAA group and had significantly better lung functions (VC, FEV1, TLCO). Patients with sarcoidosis above 60 years of age had significantly higher percentages of neutrophils in BALF compared with younger patients. BALF percentage of neutrophils positively correlated with age. ConclusionsPresented results may support the hypothesis that reactivity of immune system changes during the life, which may result in different manifestation of interstitial lung diseases according to age.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13433" target="_blank" >NT13433: Imunopatogenetický podklad fibrogeneze u intersticiálních plicních procesů, biomarkery fibrogeneze</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CLINICAL RESPIRATORY JOURNAL

ISSN

1752-6981

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

39-44

Kód UT WoS článku

000347381800007

EID výsledku v databázi Scopus

—