Neuropathological post-mortem examination of the brain and the spinal cord in ten key points - What can a neurologist expect from the neuropathologist's confirmation of the clinical diagnosis in neurodegenerative diseases?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F18%3AN0000045" target="_blank" >RIV/00064190:_____/18:N0000045 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.14735/amcsnn2018109" target="_blank" >http://dx.doi.org/10.14735/amcsnn2018109</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2018109" target="_blank" >10.14735/amcsnn2018109</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neuropathological post-mortem examination of the brain and the spinal cord in ten key points - What can a neurologist expect from the neuropathologist's confirmation of the clinical diagnosis in neurodegenerative diseases?

Popis výsledku v původním jazyce

Standardized brain and spinal cord autopsy is a key feedback mechanism for clinical diagnosis of neurodegenerative diseases. Clinical diagnostic criteria in neurodegenerative disorders reach the "pos sible" and "probable" levels. Neuropathological brain examination is often the only diagnostic modality able to confirm the "defi nite" level of diagnosis in dementia, behavior disorders and movement disorders and thus serves as an invaluable feedback for the clinician; and in clinical studies, it is used to assess therapy-related changes and validate potential diagnostic and prognostic biomarkers. The brain and spinal cord autopsy is performed following a standardized protocol analyzing all diagnostically relevant structures. Precise diagnostic procedures are performed using standard and special histological and histochemical staining; however, only a standardized set of special immunohistochemical investigations can confirm the precise neuropathological diagnosis in neurodegenerative diseases. The purpose of the article is to provide clinical neurologists in 10 points with a brief and practical overview about the usefulness of brain and spinal cord autopsy in neurodegenerative disease and about what the clinician can expect from the neuropathological protocol.

Název v anglickém jazyce

Neuropathological post-mortem examination of the brain and the spinal cord in ten key points - What can a neurologist expect from the neuropathologist's confirmation of the clinical diagnosis in neurodegenerative diseases?

Popis výsledku anglicky

Standardized brain and spinal cord autopsy is a key feedback mechanism for clinical diagnosis of neurodegenerative diseases. Clinical diagnostic criteria in neurodegenerative disorders reach the "pos sible" and "probable" levels. Neuropathological brain examination is often the only diagnostic modality able to confirm the "defi nite" level of diagnosis in dementia, behavior disorders and movement disorders and thus serves as an invaluable feedback for the clinician; and in clinical studies, it is used to assess therapy-related changes and validate potential diagnostic and prognostic biomarkers. The brain and spinal cord autopsy is performed following a standardized protocol analyzing all diagnostically relevant structures. Precise diagnostic procedures are performed using standard and special histological and histochemical staining; however, only a standardized set of special immunohistochemical investigations can confirm the precise neuropathological diagnosis in neurodegenerative diseases. The purpose of the article is to provide clinical neurologists in 10 points with a brief and practical overview about the usefulness of brain and spinal cord autopsy in neurodegenerative disease and about what the clinician can expect from the neuropathological protocol.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ČESKÁ A SLOVENSKÁ NEUROLOGIE A NEUROCHIRURGIE

ISSN

1210-7859

e-ISSN

1802-4041

Svazek periodika

81

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

109-114

Kód UT WoS článku

000429303400020

EID výsledku v databázi Scopus

2-s2.0-85041724271