Left ventricular hypertrophy in females with hypertension is associated with a poor prognosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F18%3AN0000130" target="_blank" >RIV/00064190:_____/18:N0000130 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.ijcard.2018.01.092" target="_blank" >https://doi.org/10.1016/j.ijcard.2018.01.092</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2018.01.092" target="_blank" >10.1016/j.ijcard.2018.01.092</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Left ventricular hypertrophy in females with hypertension is associated with a poor prognosis

Popis výsledku v původním jazyce

Background: In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH). Methods: 12,329 women and men with hypertension and free from prevalent cardiovascular disease enrolled in the prospective Campania Salute Network registry were followed over a median of 4.1 years. Subjects were grouped according to the absence or the presence of LVH identified by echocardiography using validated sex-specific cut-off values of LV mass index (N47 g/m2.7 in women and N50 g/m2.7 in men). Main outcome was major cardiovascular events (MACE; combined acute coronary syndromes, stroke, hospitalization for heart failure and incident atrial fibrillation). Results: The cardiovascular risk profile accompanying LVH did not differ between sexes, but presence of obesity and diabetes carried higher probability for LVH in women, and LVH was more prevalent in women than men (43.4 vs. 32.1%, p b 0.001). Among patients without LVH (n = 7764), women had a 35% lower hazard rate (HR) for MACE (n = 179) than men (95% confidence interval [CI] 0.44–0.96, p = 0.031) in Cox regression analysis adjusting for cardiovascular risk factors and antihypertensive treatment during follow up. In contrast, among patients with LVH (n = 4565), women had a similar HR for MACE as men (HR 0.94 [95% CI 0.69–1.30], p = 0.720). Conclusion: This study demonstrates that presence of LVH in hypertension offsets the female sex-protection in cardiovascular risk. Thus among hypertensive subjects with LVH, women and men have comparable cardiovascular risk.

Název v anglickém jazyce

Left ventricular hypertrophy in females with hypertension is associated with a poor prognosis

Popis výsledku anglicky

Background: In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH). Methods: 12,329 women and men with hypertension and free from prevalent cardiovascular disease enrolled in the prospective Campania Salute Network registry were followed over a median of 4.1 years. Subjects were grouped according to the absence or the presence of LVH identified by echocardiography using validated sex-specific cut-off values of LV mass index (N47 g/m2.7 in women and N50 g/m2.7 in men). Main outcome was major cardiovascular events (MACE; combined acute coronary syndromes, stroke, hospitalization for heart failure and incident atrial fibrillation). Results: The cardiovascular risk profile accompanying LVH did not differ between sexes, but presence of obesity and diabetes carried higher probability for LVH in women, and LVH was more prevalent in women than men (43.4 vs. 32.1%, p b 0.001). Among patients without LVH (n = 7764), women had a 35% lower hazard rate (HR) for MACE (n = 179) than men (95% confidence interval [CI] 0.44–0.96, p = 0.031) in Cox regression analysis adjusting for cardiovascular risk factors and antihypertensive treatment during follow up. In contrast, among patients with LVH (n = 4565), women had a similar HR for MACE as men (HR 0.94 [95% CI 0.69–1.30], p = 0.720). Conclusion: This study demonstrates that presence of LVH in hypertension offsets the female sex-protection in cardiovascular risk. Thus among hypertensive subjects with LVH, women and men have comparable cardiovascular risk.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF CARDIOLOGY

ISSN

0167-5273

e-ISSN

1874-1754

Svazek periodika

258

Číslo periodika v rámci svazku

05/2018

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

2

Strana od-do

277-278

Kód UT WoS článku

000427605700059

EID výsledku v databázi Scopus

2-s2.0-85043469222