Ten Years' Experience with the Discontinuation of the Bacillus Calmette-Guerin Vaccination in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000070" target="_blank" >RIV/00064190:_____/21:N0000070 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10428931 RIV/00216208:11130/21:10428931

Výsledek na webu

<a href="http://dx.doi.org/10.4103/ijmy.ijmy_85_21" target="_blank" >http://dx.doi.org/10.4103/ijmy.ijmy_85_21</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4103/ijmy.ijmy_85_21" target="_blank" >10.4103/ijmy.ijmy_85_21</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ten Years' Experience with the Discontinuation of the Bacillus Calmette-Guerin Vaccination in the Czech Republic

Popis výsledku v původním jazyce

Background: Bacillus Calmette-Guerin (BCG) vaccination programs were introduced in Czechoslovakia more than 60 years ago under a quite different epidemiological situation than that of today. Compulsory mass BCG vaccination was abolished in November 2010 and changed to a selective vaccination program for infants at high risk of contracting tuberculosis (TB). Methods: This work sets out to ascertain the risk of TB and nontuberculous mycobacterial (NTM) infection in the 10-year period following the change to the vaccination program and to compare this with the same period of time when mass BCG vaccination was compulsory. Descriptive study. Statistical analysis of the incidence of tuberculosis and non-tuberculous mycobacteriosis as reported in the TB register in years 2001-2020. Conclusions: The incidence trend of TB in children in both monitored time periods is identical and statistically significantly decreasing (P < 0.001). In the first monitored period, the incidence trend of NTM cervical lymphadenitis in children is degressive and is not statistically significant (P = 0.561). However, in the second monitored period, the trend increases and is statistically significant (P < 0.001); in every compared 2-consecutive year period, there is an increase of 8%. These findings indicate that the change from mass BCG vaccination to selective vaccination of high-risk newborns and the abolishment of BCG revaccination can be recommended, so long as a keen eye is kept on NTM caused lymphadenitis.

Název v anglickém jazyce

Ten Years' Experience with the Discontinuation of the Bacillus Calmette-Guerin Vaccination in the Czech Republic

Popis výsledku anglicky

Background: Bacillus Calmette-Guerin (BCG) vaccination programs were introduced in Czechoslovakia more than 60 years ago under a quite different epidemiological situation than that of today. Compulsory mass BCG vaccination was abolished in November 2010 and changed to a selective vaccination program for infants at high risk of contracting tuberculosis (TB). Methods: This work sets out to ascertain the risk of TB and nontuberculous mycobacterial (NTM) infection in the 10-year period following the change to the vaccination program and to compare this with the same period of time when mass BCG vaccination was compulsory. Descriptive study. Statistical analysis of the incidence of tuberculosis and non-tuberculous mycobacteriosis as reported in the TB register in years 2001-2020. Conclusions: The incidence trend of TB in children in both monitored time periods is identical and statistically significantly decreasing (P < 0.001). In the first monitored period, the incidence trend of NTM cervical lymphadenitis in children is degressive and is not statistically significant (P = 0.561). However, in the second monitored period, the trend increases and is statistically significant (P < 0.001); in every compared 2-consecutive year period, there is an increase of 8%. These findings indicate that the change from mass BCG vaccination to selective vaccination of high-risk newborns and the abolishment of BCG revaccination can be recommended, so long as a keen eye is kept on NTM caused lymphadenitis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY

ISSN

2212-5531

e-ISSN

2212-554X

Svazek periodika

10

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

6

Strana od-do

193-198

Kód UT WoS článku

000668753800015

EID výsledku v databázi Scopus

2-s2.0-85108649596