Hypertrophic remodelling of retinal arterioles in patients with congestive heart failure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000079" target="_blank" >RIV/00064190:_____/21:N0000079 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10428032

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ehf2.13334" target="_blank" >http://dx.doi.org/10.1002/ehf2.13334</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ehf2.13334" target="_blank" >10.1002/ehf2.13334</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hypertrophic remodelling of retinal arterioles in patients with congestive heart failure

Popis výsledku v původním jazyce

Aims Analysis of microvascular parameters in the retinal circulation-known to reflect those in the systemic circulation-allows us to differentiate between eutrophic and hypertrophic remodelling of small arteries. This study aimed to examine microvascular changes in patients with congestive heart failure (CHF) and reduced as well as mid-range ejection fraction. Methods and results Forty subjects with CHF underwent measurement of retinal capillary flow (RCF), wall-to-lumen ratio (WLR), vessel and lumen diameter, wall thickness, and wall cross-sectional area (WCSA) of retinal arterioles of the right eye by scanning laser Doppler flowmetry (SLDF). Applying a matched pair approach, we compared this group with reference values of age-matched controls from a random sample in the population of Pilsen, Czech Republic. There was no significant difference in RCF and WLR between the groups (RCF: P = 0.513; WLR: P = 0.106). In contrast, wall thickness and WCSA, indicators of hypertrophic remodelling, were higher in CHF subjects (WT: 15.0 +/- 4.2 vs. 12.7 +/- 4.2 mu m, P = 0.021; WCSA: 4437.6 +/- 1314.5 vs. 3615.9 +/- 1567.8 mu m(2), P = 0.014). Similarly, vessel (109.4 +/- 11.1 vs. 100.5 +/- 14.4 mu m, P = 0.002) and lumen diameter (79.0 +/- 7.9 vs. 75.2 +/- 8.5 mu m, P = 0.009) were increased in CHF. Conclusions In CHF subjects, we observed hypertrophic remodelling of retinal arterioles indicative of similar changes of small resistance arteries in the systemic circulation. Microvascular structure and function assessed by SLDF may thereby represent a useful, non-invasive method for monitoring of microvascular damage in patients with CHF and may offer innovative treatment targets for new CHF therapies.

Název v anglickém jazyce

Hypertrophic remodelling of retinal arterioles in patients with congestive heart failure

Popis výsledku anglicky

Aims Analysis of microvascular parameters in the retinal circulation-known to reflect those in the systemic circulation-allows us to differentiate between eutrophic and hypertrophic remodelling of small arteries. This study aimed to examine microvascular changes in patients with congestive heart failure (CHF) and reduced as well as mid-range ejection fraction. Methods and results Forty subjects with CHF underwent measurement of retinal capillary flow (RCF), wall-to-lumen ratio (WLR), vessel and lumen diameter, wall thickness, and wall cross-sectional area (WCSA) of retinal arterioles of the right eye by scanning laser Doppler flowmetry (SLDF). Applying a matched pair approach, we compared this group with reference values of age-matched controls from a random sample in the population of Pilsen, Czech Republic. There was no significant difference in RCF and WLR between the groups (RCF: P = 0.513; WLR: P = 0.106). In contrast, wall thickness and WCSA, indicators of hypertrophic remodelling, were higher in CHF subjects (WT: 15.0 +/- 4.2 vs. 12.7 +/- 4.2 mu m, P = 0.021; WCSA: 4437.6 +/- 1314.5 vs. 3615.9 +/- 1567.8 mu m(2), P = 0.014). Similarly, vessel (109.4 +/- 11.1 vs. 100.5 +/- 14.4 mu m, P = 0.002) and lumen diameter (79.0 +/- 7.9 vs. 75.2 +/- 8.5 mu m, P = 0.009) were increased in CHF. Conclusions In CHF subjects, we observed hypertrophic remodelling of retinal arterioles indicative of similar changes of small resistance arteries in the systemic circulation. Microvascular structure and function assessed by SLDF may thereby represent a useful, non-invasive method for monitoring of microvascular damage in patients with CHF and may offer innovative treatment targets for new CHF therapies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV15-27109A" target="_blank" >NV15-27109A: Dlouhodobé trendy hlavních kardiovaskulárních rizikových faktorů a jejich prediktivní hodnota v náhodně vybraném populačním vzorku, Czech post-MONICA</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ESC HEART FAILURE

ISSN

2055-5822

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1892-1900

Kód UT WoS článku

000634928000001

EID výsledku v databázi Scopus

2-s2.0-85103429578