Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000113" target="_blank" >RIV/00064190:_____/21:N0000113 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10440674 RIV/68378041:_____/21:00560420

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clnesp.2021.09.740" target="_blank" >http://dx.doi.org/10.1016/j.clnesp.2021.09.740</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clnesp.2021.09.740" target="_blank" >10.1016/j.clnesp.2021.09.740</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

Popis výsledku v původním jazyce

Background & aims: Short chain fatty acid (SCFAs) are bacterially derived metabolites suggested to have protective roles against colorectal cancer (CRC) development. However, there is sparse evidence from epidemiological studies in this context. Here, we assessed whether circulating SCFA concentrations varied in patients with colorectal adenomas (CRA) and CRC. Methods: Levels of seven SCFAs were extracted from plasma samples and determined by gas chromatography for 213 individuals from Ireland and the Czech Republic (CRC, n = 84; CRA, n = 66; controls, n = 63). Results: In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values = 0.016 and 0.043). Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02; 95% Confidence interval (CI): 1.00-1.03; OR: 1.29; 95% CI: 1.05 -1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92; 95% CI: 0.86-0.99; OR: 0.67; 95% CI: 0.44-1.00). In the Irish cohort, levels of SCFAs were not associated with CRC risk. Conclusions: The association with colorectal neoplasia varied between the studied SCFAs. Future studies need to confirm these findings and address the mechanism of how these acids may promote or prevent colorectal carcinogenesis. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.

Název v anglickém jazyce

Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

Popis výsledku anglicky

Background & aims: Short chain fatty acid (SCFAs) are bacterially derived metabolites suggested to have protective roles against colorectal cancer (CRC) development. However, there is sparse evidence from epidemiological studies in this context. Here, we assessed whether circulating SCFA concentrations varied in patients with colorectal adenomas (CRA) and CRC. Methods: Levels of seven SCFAs were extracted from plasma samples and determined by gas chromatography for 213 individuals from Ireland and the Czech Republic (CRC, n = 84; CRA, n = 66; controls, n = 63). Results: In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values = 0.016 and 0.043). Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02; 95% Confidence interval (CI): 1.00-1.03; OR: 1.29; 95% CI: 1.05 -1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92; 95% CI: 0.86-0.99; OR: 0.67; 95% CI: 0.44-1.00). In the Irish cohort, levels of SCFAs were not associated with CRC risk. Conclusions: The association with colorectal neoplasia varied between the studied SCFAs. Future studies need to confirm these findings and address the mechanism of how these acids may promote or prevent colorectal carcinogenesis. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

<a href="/cs/project/GA20-03997S" target="_blank" >GA20-03997S: Vliv mikrobiálních metabolitů a diety na genom a epigenom při vzniku kolorektálního karcinomu</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CLINICAL NUTRITION ESPEN

ISSN

2405-4577

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

297-304

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

297-304

Kód UT WoS článku

000757020900040

EID výsledku v databázi Scopus

2-s2.0-85117707788