Re: Laura Elst, Gino Philips, Kaat Vandermaesen, et al. Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization. Eur Urol. In press https://doi.org/10.1016/j.eururo.2024.03.038

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F24%3A10001261" target="_blank" >RIV/00064190:_____/24:10001261 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.eururo.2024.07.029" target="_blank" >https://doi.org/10.1016/j.eururo.2024.07.029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eururo.2024.07.029" target="_blank" >10.1016/j.eururo.2024.07.029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Re: Laura Elst, Gino Philips, Kaat Vandermaesen, et al. Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization. Eur Urol. In press https://doi.org/10.1016/j.eururo.2024.03.038

Popis výsledku v původním jazyce

Penile squamous cell carcinoma (pSCC) is a rare genitourinary tumor associated with poorer prognosis in comparison to more common urological cancers. Elst and colleagues report on a novel single-cell RNA sequencing analysis that identified TP53 mutations as a crucial marker of aggressive cancer, independent of human papillomavirus (HPV) status. TP53-mutated pSCCs exhibited epithelial-mesenchymal transition (EMT) transcriptional signatures. Morphologically, this was evident as high tumor budding, which is a well-known indicator of metastasis and poor prognosis across various cancers. Our group recently described the negative prognostic impact of tumor budding, mutated p53 expression profiles (n = 152), and high tumor mutational burden (n = 136) in relatively large cohorts.

Název v anglickém jazyce

Re: Laura Elst, Gino Philips, Kaat Vandermaesen, et al. Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization. Eur Urol. In press https://doi.org/10.1016/j.eururo.2024.03.038

Popis výsledku anglicky

Penile squamous cell carcinoma (pSCC) is a rare genitourinary tumor associated with poorer prognosis in comparison to more common urological cancers. Elst and colleagues report on a novel single-cell RNA sequencing analysis that identified TP53 mutations as a crucial marker of aggressive cancer, independent of human papillomavirus (HPV) status. TP53-mutated pSCCs exhibited epithelial-mesenchymal transition (EMT) transcriptional signatures. Morphologically, this was evident as high tumor budding, which is a well-known indicator of metastasis and poor prognosis across various cancers. Our group recently described the negative prognostic impact of tumor budding, mutated p53 expression profiles (n = 152), and high tumor mutational burden (n = 136) in relatively large cohorts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

<a href="/cs/project/NU21J-03-00019" target="_blank" >NU21J-03-00019: Prognosticky významné prediktivní znaky karcinomu penisu: molekulární a morfologická studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EUROPEAN UROLOGY

ISSN

0302-2838

e-ISSN

1873-7560

Svazek periodika

86

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

2

Strana od-do

"e145"-"e146"

Kód UT WoS článku

001386187800001

EID výsledku v databázi Scopus

2-s2.0-85203066743