Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F24%3A10001263" target="_blank" >RIV/00064190:_____/24:10001263 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.arbres.2024.06.019" target="_blank" >https://doi.org/10.1016/j.arbres.2024.06.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.arbres.2024.06.019" target="_blank" >10.1016/j.arbres.2024.06.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry

Popis výsledku v původním jazyce

Background: Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort study. Methods: Baseline data from PiZZ individuals, enrolled in the registry with complete data on sex and smoking history were analysed by group comparisons and binary logistic regression analyses. Results: 1283 patients with AATD, 49.3% women were analysed. Females reported less tobacco consumption (16.8 ± 12.2 vs. 19.6 ± 14.5 PY, p = 0.006), occupational exposures towards gases, dusts or asbestos (p &lt; 0.005 each) and consumed less alcohol (5.5 ± 7.6 vs. 8.4 ± 10.3 u/week, p &lt; 0.001). Females reported COPD (41% vs. 57%, p &lt; 0.001) and liver disease (11% vs. 20%, p &lt; 0.001) less often. However, they had a higher prevalence of bronchiectasis (24% vs. 13%, p &lt; 0.001). Despite better lung function (FEV1%pred. 73.6 ± 29.9 vs. 62.7 ± 29.5, p &lt; 0.001) females reported a similar symptom burden (CAT 13.4 ± 9.5 vs. 12.5 ± 8.9, p = ns) and exacerbation frequency (at least one in the previous year 30% vs. 26%, p = ns) compared to males. In multivariate analyses, female sex was an independent risk factor for exacerbations in the previous year OR 1.6 p = 0.001 in addition to smoking history, COPD, asthma and bronchiectasis and was also identified as risk factors for symptom burden (CAT ≥ 10) OR 1.4 p = 0.014 besides age, BMI, COPD and smoking history. Conclusion: Men had higher rates of COPD and liver disease, women were more likely to have bronchiectasis. Women&apos;s higher symptom burden and exacerbation frequency suggest they may need tailored treatment approaches. © 2024 The Author(s)

Název v anglickém jazyce

Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry

Popis výsledku anglicky

Background: Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort study. Methods: Baseline data from PiZZ individuals, enrolled in the registry with complete data on sex and smoking history were analysed by group comparisons and binary logistic regression analyses. Results: 1283 patients with AATD, 49.3% women were analysed. Females reported less tobacco consumption (16.8 ± 12.2 vs. 19.6 ± 14.5 PY, p = 0.006), occupational exposures towards gases, dusts or asbestos (p &lt; 0.005 each) and consumed less alcohol (5.5 ± 7.6 vs. 8.4 ± 10.3 u/week, p &lt; 0.001). Females reported COPD (41% vs. 57%, p &lt; 0.001) and liver disease (11% vs. 20%, p &lt; 0.001) less often. However, they had a higher prevalence of bronchiectasis (24% vs. 13%, p &lt; 0.001). Despite better lung function (FEV1%pred. 73.6 ± 29.9 vs. 62.7 ± 29.5, p &lt; 0.001) females reported a similar symptom burden (CAT 13.4 ± 9.5 vs. 12.5 ± 8.9, p = ns) and exacerbation frequency (at least one in the previous year 30% vs. 26%, p = ns) compared to males. In multivariate analyses, female sex was an independent risk factor for exacerbations in the previous year OR 1.6 p = 0.001 in addition to smoking history, COPD, asthma and bronchiectasis and was also identified as risk factors for symptom burden (CAT ≥ 10) OR 1.4 p = 0.014 besides age, BMI, COPD and smoking history. Conclusion: Men had higher rates of COPD and liver disease, women were more likely to have bronchiectasis. Women&apos;s higher symptom burden and exacerbation frequency suggest they may need tailored treatment approaches. © 2024 The Author(s)

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archivos de Bronconeumologia

ISSN

0300-2896

e-ISSN

—

Svazek periodika

61

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

8

Strana od-do

22-30

Kód UT WoS článku

001416342900001

EID výsledku v databázi Scopus

2-s2.0-85199770918