Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5366" target="_blank" >RIV/00064203:_____/09:5366 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/09:5366
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens
Popis výsledku v původním jazyce
Little is known how maternal hyperglycaemia influences the specific immune response of her baby. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effectof maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester,newborns with T1D father, newborns witha mother treated for either gestational or type 2 diabetes and control newborns were studied. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers and also in mothers with perfect diabetes compensation. It seems that maternal 'sweet' as well as 'autoimmune environment' may both lead to lower occurrence of T1D within their offspring.
Název v anglickém jazyce
Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens
Popis výsledku anglicky
Little is known how maternal hyperglycaemia influences the specific immune response of her baby. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effectof maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester,newborns with T1D father, newborns witha mother treated for either gestational or type 2 diabetes and control newborns were studied. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers and also in mothers with perfect diabetes compensation. It seems that maternal 'sweet' as well as 'autoimmune environment' may both lead to lower occurrence of T1D within their offspring.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2009
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Scandinavian Journal of Immunology
ISSN
0300-9475
e-ISSN
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Svazek periodika
70
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
NO - Norské království
Počet stran výsledku
10
Strana od-do
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Kód UT WoS článku
000268061600010
EID výsledku v databázi Scopus
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