Reactivity to Helicobacter pylori Antigens in Patients Suffering from Thyroid Gland Autoimmunity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5419" target="_blank" >RIV/00064203:_____/09:5419 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/09:00202615 RIV/00216208:11130/09:5419 RIV/00216208:11140/09:00202110

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Reactivity to Helicobacter pylori Antigens in Patients Suffering from Thyroid Gland Autoimmunity

Popis výsledku v původním jazyce

In this study we concentrated on relationship between Helicobacter pylori and autoimmune thyroiditis. Forty seven AT patients and 34 healthy controls were enrolled. Study subjects were split according to Helicobacter pylori positivity. Their peripheral blood mononuclear cells were stimulated by H.pylori lysate and its lipopolysacharide (LPS) and cytokine production was studied. We observed different "reactivity pattern" to H. pylori within groups with low basal cytokine and chemokine production in healthy H.pylori negative controls but with clear specific response in IFN-gamma and TGF-beta production in this group. Adequate immune reaction which is joined to appropriate immunoregulation leads to prevention of the chronic infection and on the other handmay prevent the development of "connected" diseases such as autoimmune.

Název v anglickém jazyce

Reactivity to Helicobacter pylori Antigens in Patients Suffering from Thyroid Gland Autoimmunity

Popis výsledku anglicky

In this study we concentrated on relationship between Helicobacter pylori and autoimmune thyroiditis. Forty seven AT patients and 34 healthy controls were enrolled. Study subjects were split according to Helicobacter pylori positivity. Their peripheral blood mononuclear cells were stimulated by H.pylori lysate and its lipopolysacharide (LPS) and cytokine production was studied. We observed different "reactivity pattern" to H. pylori within groups with low basal cytokine and chemokine production in healthy H.pylori negative controls but with clear specific response in IFN-gamma and TGF-beta production in this group. Adequate immune reaction which is joined to appropriate immunoregulation leads to prevention of the chronic infection and on the other handmay prevent the development of "connected" diseases such as autoimmune.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NR8887" target="_blank" >NR8887: Juvenilní lymfocytární tyreoiditis a současný výskyt infekce Helicobacter pylori</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Clinical Endocrinology & Diabetes

ISSN

0947-7349

e-ISSN

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Svazek periodika

117

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000270680100011

EID výsledku v databázi Scopus

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