Prevalence of HHV-6 Integrated Chromosomally Among Children Treated for Acute Lymphoblastic or Myeloid Leukemia in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5430" target="_blank" >RIV/00064203:_____/09:5430 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/09:5430 RIV/65269705:_____/09:#0000852

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence of HHV-6 Integrated Chromosomally Among Children Treated for Acute Lymphoblastic or Myeloid Leukemia in the Czech Republic

Popis výsledku v původním jazyce

Chromosomal integration (CI) of human herpesvirus 6 (HHV-6) is relatively rare new phenomenon. Samples from 339 pediatric patients treated for leukemia in the Czech Republic between the years 1995?2007 were tested retrospectively for HHV-6 DNA quantity,normalized to 100,000 human genome quivalents and expressed in normalised viral copies (NVCs). HHV-6 DNA was detected in 107 samples from 91 patients (26.8%). In majority of samples (99) median 1.84 NVCs was detected. A high viral load about 100,000 NVCswas detected in 5 patients (1.5%; median 140,150 NVCs), confirmed as CI-HHV-6 carriers by a detection of HHV-6 DNA in hair follicles/nails. In all but one patient HHV-6 variant B was detected. None patient with CI-HHV-6 had complications attributable toHHV-6 infection. Prevalence of CI-HHV-6 in childhood leukemia does not differ from other patients or healthy populations.

Název v anglickém jazyce

Prevalence of HHV-6 Integrated Chromosomally Among Children Treated for Acute Lymphoblastic or Myeloid Leukemia in the Czech Republic

Popis výsledku anglicky

Chromosomal integration (CI) of human herpesvirus 6 (HHV-6) is relatively rare new phenomenon. Samples from 339 pediatric patients treated for leukemia in the Czech Republic between the years 1995?2007 were tested retrospectively for HHV-6 DNA quantity,normalized to 100,000 human genome quivalents and expressed in normalised viral copies (NVCs). HHV-6 DNA was detected in 107 samples from 91 patients (26.8%). In majority of samples (99) median 1.84 NVCs was detected. A high viral load about 100,000 NVCswas detected in 5 patients (1.5%; median 140,150 NVCs), confirmed as CI-HHV-6 carriers by a detection of HHV-6 DNA in hair follicles/nails. In all but one patient HHV-6 variant B was detected. None patient with CI-HHV-6 had complications attributable toHHV-6 infection. Prevalence of CI-HHV-6 in childhood leukemia does not differ from other patients or healthy populations.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medical Virology

ISSN

0146-6615

e-ISSN

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Svazek periodika

81

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000262095300008

EID výsledku v databázi Scopus

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