Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6375" target="_blank" >RIV/00064203:_____/10:6375 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/10:6375

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery

Popis výsledku v původním jazyce

PURPOSE. To determine platinum (Pt) concentrations and area under the concentration versus time curve (AUC) of the vitreous humor after periocular or transcorneal intravitreal administration of carboplatin in rabbits. METHODS. Eighteen albino rabbits were included in an in vivo experiment. Each animal received a single dose of either 30 mg of carboplatin by periocular injection (POI30 group: n=6) or 15 mg by periocular injection (POI15 group: n=6), or 0.05 mg by transcorneal intravitreal injection (TIIgroup: n=6), respectively, into the right eye. RESULTS. Pt concentration was mostly <1 mg/L (0-3.15 mg/L) in the vitreous humor samples and >= 2 mg/L (2.33-7.3 mg/L) in the blood samples 1 hour after administration in POI groups. Markedly higher Pt concentrations were found 1 hour after intravitreal (Ill) administration (10.285-66.759 mg/L) and decreased below 1 mg/L no less than 168 hours after administration.

Název v anglickém jazyce

Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery

Popis výsledku anglicky

PURPOSE. To determine platinum (Pt) concentrations and area under the concentration versus time curve (AUC) of the vitreous humor after periocular or transcorneal intravitreal administration of carboplatin in rabbits. METHODS. Eighteen albino rabbits were included in an in vivo experiment. Each animal received a single dose of either 30 mg of carboplatin by periocular injection (POI30 group: n=6) or 15 mg by periocular injection (POI15 group: n=6), or 0.05 mg by transcorneal intravitreal injection (TIIgroup: n=6), respectively, into the right eye. RESULTS. Pt concentration was mostly <1 mg/L (0-3.15 mg/L) in the vitreous humor samples and >= 2 mg/L (2.33-7.3 mg/L) in the blood samples 1 hour after administration in POI groups. Markedly higher Pt concentrations were found 1 hour after intravitreal (Ill) administration (10.285-66.759 mg/L) and decreased below 1 mg/L no less than 168 hours after administration.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9532" target="_blank" >NR9532: Sledování dynamiky koncentrace cytostik ve sklivcovém prostoru králičího bulbu po transkorneální a subkonjunktivální aplikaci</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Ophthalmology

ISSN

1120-6721

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000280191600016

EID výsledku v databázi Scopus

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