Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia - an individual patient data meta-analysis involving 5659 children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A7277" target="_blank" >RIV/00064203:_____/10:7277 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/10:7277

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/20331462" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/20331462</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia - an individual patient data meta-analysis involving 5659 children

Popis výsledku v původním jazyce

Vincristine plus steroid pulses have long been a part of maintenance treatment in many protocols for childhood acute lymphoblastic leukaemia (ALL). A collaborative individual patient data meta-analysis of all randomised trials of the addition of vincristine plus prednisone/prednisolone (VP) pulses in childhood ALL was updated and extended to include trials comparing vincristine plus dexamethasone (VD) pulses to maintenance without pulses. VP pulses improved event-free survival (EFS) (70 center dot 1% vs. 62 center dot 0% at 5 years; odds ratio (OR) = 0 center dot 71; 95% confidence interval (CI) = 0 center dot 61-0 center dot 84; P = 0 center dot 00004); VD pulses did not have a significant effect (80 center dot 9% vs. 79 center dot 9% 5 year EFS; OR =0 center dot 94; 95% CI = 0 center dot 80-1 center dot 11; P = 0 center dot 5). Heterogeneity between groups (VP or VD) was significant (P = 0 center dot 02). Neither treatment clearly affected overall survival. The difference between th

Název v anglickém jazyce

Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia - an individual patient data meta-analysis involving 5659 children

Popis výsledku anglicky

Vincristine plus steroid pulses have long been a part of maintenance treatment in many protocols for childhood acute lymphoblastic leukaemia (ALL). A collaborative individual patient data meta-analysis of all randomised trials of the addition of vincristine plus prednisone/prednisolone (VP) pulses in childhood ALL was updated and extended to include trials comparing vincristine plus dexamethasone (VD) pulses to maintenance without pulses. VP pulses improved event-free survival (EFS) (70 center dot 1% vs. 62 center dot 0% at 5 years; odds ratio (OR) = 0 center dot 71; 95% confidence interval (CI) = 0 center dot 61-0 center dot 84; P = 0 center dot 00004); VD pulses did not have a significant effect (80 center dot 9% vs. 79 center dot 9% 5 year EFS; OR =0 center dot 94; 95% CI = 0 center dot 80-1 center dot 11; P = 0 center dot 5). Heterogeneity between groups (VP or VD) was significant (P = 0 center dot 02). Neither treatment clearly affected overall survival. The difference between th

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal of Haematology

ISSN

0007-1048

e-ISSN

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Svazek periodika

149

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

722-733

Kód UT WoS článku

000277791000009

EID výsledku v databázi Scopus

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