Urinary transforming growth factor-beta 1 in children with obstructive uropathy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7032" target="_blank" >RIV/00064203:_____/11:7032 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/11:7032
Výsledek na webu
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21382126" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21382126</a>
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Urinary transforming growth factor-beta 1 in children with obstructive uropathy
Popis výsledku v původním jazyce
Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those withNOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0
Název v anglickém jazyce
Urinary transforming growth factor-beta 1 in children with obstructive uropathy
Popis výsledku anglicky
Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those withNOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FP - Ostatní lékařské obory
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Nephrology
ISSN
1320-5358
e-ISSN
—
Svazek periodika
16
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
AU - Austrálie
Počet stran výsledku
4
Strana od-do
595-598
Kód UT WoS článku
000293240900009
EID výsledku v databázi Scopus
—