Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7165" target="_blank" >RIV/00064203:_____/11:7165 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/11:7165

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21821607" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21821607</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy

Popis výsledku v původním jazyce

Aims Hypertrophic cardiomyopathy (HCM) is predominantly associated with left ventricular outflow tract (LVOT) obstruction. The assessment of the obstruction with a provoking test should be a routine part of HCM evaluation. The aim of the study was to determine the utility of a sublingual spray application of isosorbide dinitrate (ISDN) for detection of an obstruction. Methods and results We have prospectively analysed 77 consecutive HCM patients, measuring the LVOT gradient at rest, using the sublingualspray application of ISDN (2.5 mg; after 2, 5, and 10 min), and with exercise echocardiography. An obstruction was defined as a gradient >= 30 mmHg. An obstruction was present in 15 patients (19%) at rest, in 42 patients (55%) after ISDN, and in 55 patients (71%) after exercise. The ISDN test had a sensitivity of 76% and the specificity of 100% relative to exercise echocardiography, while at-rest measurements had a sensitivity of 27% and a specificity of 100%. The chronological differen

Název v anglickém jazyce

Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy

Popis výsledku anglicky

Aims Hypertrophic cardiomyopathy (HCM) is predominantly associated with left ventricular outflow tract (LVOT) obstruction. The assessment of the obstruction with a provoking test should be a routine part of HCM evaluation. The aim of the study was to determine the utility of a sublingual spray application of isosorbide dinitrate (ISDN) for detection of an obstruction. Methods and results We have prospectively analysed 77 consecutive HCM patients, measuring the LVOT gradient at rest, using the sublingualspray application of ISDN (2.5 mg; after 2, 5, and 10 min), and with exercise echocardiography. An obstruction was defined as a gradient >= 30 mmHg. An obstruction was present in 15 patients (19%) at rest, in 42 patients (55%) after ISDN, and in 55 patients (71%) after exercise. The ISDN test had a sensitivity of 76% and the specificity of 100% relative to exercise echocardiography, while at-rest measurements had a sensitivity of 27% and a specificity of 100%. The chronological differen

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11401" target="_blank" >NT11401: Význam spánkové apnoe v patofyziologii hypertrofické kardiomyopatie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Echocardiography

ISSN

1525-2167

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

684-687

Kód UT WoS článku

000295961300011

EID výsledku v databázi Scopus

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