Randomized Double-Blind Study: Wound-Healing Effects of a Symphytum Herb Extract Cream (Symphytum x uplandicum NYMAN) in Children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8186" target="_blank" >RIV/00064203:_____/12:8186 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/12:8186

Výsledek na webu

<a href="http://dx.doi.org/10.1055/s-0032-1308981" target="_blank" >http://dx.doi.org/10.1055/s-0032-1308981</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Randomized Double-Blind Study: Wound-Healing Effects of a Symphytum Herb Extract Cream (Symphytum x uplandicum NYMAN) in Children

Popis výsledku v původním jazyce

The wound healing effects of the topically applied preparation Traumaplant (R) containing a concentrate (10% active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN) were examined in a randomized, controlled, clinicaldouble-blind study. An otherwise identical low-dose preparation (1% active ingredient) was used as a control. The study population consisted of 108 children aged 3-12 years (n = 54/group) with fresh abrasions. A 50% healing rate was reached 0.9 days earlier with the higher than with the lower concentration cream. The difference in the healing rate (0.38 +/- 0.18/day [95% CI 0.33-0.4] vs. 0.26 +/- 0.14/day [95% CI 0.222-0.297]) was statistically significant (p = 0.0002). Physicians and children/parents both rated the efficacy of the 10% cream as significantly better than that of the control preparation (physicians' assessment after 2-3 and 7-9 days for verum vs. control: 90.7 and 92.6% vs. 55.6 and 74.0% of the healing rates were rated a

Název v anglickém jazyce

Randomized Double-Blind Study: Wound-Healing Effects of a Symphytum Herb Extract Cream (Symphytum x uplandicum NYMAN) in Children

Popis výsledku anglicky

The wound healing effects of the topically applied preparation Traumaplant (R) containing a concentrate (10% active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN) were examined in a randomized, controlled, clinicaldouble-blind study. An otherwise identical low-dose preparation (1% active ingredient) was used as a control. The study population consisted of 108 children aged 3-12 years (n = 54/group) with fresh abrasions. A 50% healing rate was reached 0.9 days earlier with the higher than with the lower concentration cream. The difference in the healing rate (0.38 +/- 0.18/day [95% CI 0.33-0.4] vs. 0.26 +/- 0.14/day [95% CI 0.222-0.297]) was statistically significant (p = 0.0002). Physicians and children/parents both rated the efficacy of the 10% cream as significantly better than that of the control preparation (physicians' assessment after 2-3 and 7-9 days for verum vs. control: 90.7 and 92.6% vs. 55.6 and 74.0% of the healing rates were rated a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Arzneimittel-Forschung-Drug Research

ISSN

0004-4172

e-ISSN

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Svazek periodika

62

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

285-289

Kód UT WoS článku

000307600000005

EID výsledku v databázi Scopus

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