The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8251" target="_blank" >RIV/00064203:_____/12:8251 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/12:8251

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00431-012-1833-2" target="_blank" >http://dx.doi.org/10.1007/s00431-012-1833-2</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients

Popis výsledku v původním jazyce

We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Naratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedsidemethod as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis o

Název v anglickém jazyce

The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients

Popis výsledku anglicky

We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Naratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedsidemethod as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis o

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pediatrics

ISSN

0340-6199

e-ISSN

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Svazek periodika

171

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

1

Strana od-do

1719

Kód UT WoS článku

000310810700023

EID výsledku v databázi Scopus

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