Prevalence and treatment of anti-NMDA receptor encephalitis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209568" target="_blank" >RIV/00064203:_____/13:10209568 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10209568

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S147444221370070X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S147444221370070X</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence and treatment of anti-NMDA receptor encephalitis

Popis výsledku v původním jazyce

We have been treating an 8-year-old girl with anti-NMDAR encephalitis for more than 1 year. The disease manifested with movement disorder mimicking polyradiculomyelitis. During the first week of hospital admission, the girl received intravenous immunoglobulin with no clinical response. Within 3 weeks, she developed deep coma with autonomic instability. Her serum and CSF were positive for anti-NMDAR antibodies. Plasma exchange and high-dose corticosteroids were immediately applied, followed by rituximab,with no effect. Therefore, cyclophosphamide treatment was started of which she received seven cycles. Three cycles stabilised her autonomic system, but she developed intractable motor restlessness and remained in coma. Four subsequent cycles were strengthened by removal of antibodies from peripheral blood with immunoadsorptions; nevertheless, the girl's neurological status remained unchanged.

Název v anglickém jazyce

Prevalence and treatment of anti-NMDA receptor encephalitis

Popis výsledku anglicky

We have been treating an 8-year-old girl with anti-NMDAR encephalitis for more than 1 year. The disease manifested with movement disorder mimicking polyradiculomyelitis. During the first week of hospital admission, the girl received intravenous immunoglobulin with no clinical response. Within 3 weeks, she developed deep coma with autonomic instability. Her serum and CSF were positive for anti-NMDAR antibodies. Plasma exchange and high-dose corticosteroids were immediately applied, followed by rituximab,with no effect. Therefore, cyclophosphamide treatment was started of which she received seven cycles. Three cycles stabilised her autonomic system, but she developed intractable motor restlessness and remained in coma. Four subsequent cycles were strengthened by removal of antibodies from peripheral blood with immunoadsorptions; nevertheless, the girl's neurological status remained unchanged.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lancet Neurology

ISSN

1474-4422

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

2

Strana od-do

424-425

Kód UT WoS článku

000318836700010

EID výsledku v databázi Scopus

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